2434630-30-3
Chemical Structure
γ-Secretase modulator 11 hydrochloride
- CAS No.: 2434630-30-3
- Formula:C28H23ClF2N4O2
- Molecular Weight:520.96
IUPAC Name: 5-(8-((3,4'-difluoro-[1,1'-biphenyl]-4-yl)methoxy)-2-methylimidazo[1,2-a]pyridin-3-yl)-N-methylpicolinamide hydrochloride
InChIKey: LKXRSVMSDSUZLY-UHFFFAOYSA-N
SMILES: O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=C(F)C=C5)C=C4F)=CC=CN32)C=C1)NC.[H]Cl
Biological Activity: γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease[1].
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γ-Secretase modulator 11 hydrochloride | γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease. | |||||||||||||||||||||
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