γ-Secretase modulator 11 hydrochloride
γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 2434630-30-3
- Formula: C28H23ClF2N4O2
- Molecular Weight:520.96
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 0.029 µM nM (γ-Secretase)[1]
Chemical Information
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CAS No. 2434630-30-3
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Molecular Weight 520.96
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Formula C28H23ClF2N4O2
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SMILES
O=C(C1=NC=C(C2=C(C)N=C3C(OCC4=CC=C(C5=CC=C(F)C=C5)C=C4F)=CC=CN32)C=C1)NC.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
γ-Secretase modulator 11 hydrochloride Related Classifications
HY-147720A Related Classifications
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