2866066-81-9
Chemical Structure
AChE/BACE1/GSK3β-IN-1
- CAS No.: 2866066-81-9
- Formula:C26H27FN2O4
- Molecular Weight:450.50
IUPAC Name: 4-(3-(4-((3-fluorobenzyl)amino)piperidin-1-yl)propoxy)-7H-furo[3,2-g]chromen-7-one
InChIKey: PIEYPHGYCKJMMG-UHFFFAOYSA-N
SMILES: O=C1C=CC2=C(OCCCN3CCC(NCC4=CC(F)=CC=C4)CC3)C5=C(OC=C5)C=C2O1
Biological Activity: AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 has effective inhibitory activity against AChE, BACE1 and GSK3β with IC50 values of 1.0 μM, 20 μM and 15 μM, respectively. AChE/BACE1/GSK3β-IN-1 has good blood-brain barrier penetrability, suitable bioavailability. AChE/BACE1/GSK3β-IN-1 can be used for the research of Alzheimer's disease (AD)[1].
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AChE/BACE1/GSK3β-IN-1 | AChE/BACE1/GSK3β-IN-1 is an orally active triple inhibitor of AChE/BACE1/GSK3β. AChE/BACE1/GSK3β-IN-1 has effective inhibitory activity against AChE, BACE1 and GSK3β with IC50 values of 1.0 μM, 20 μM and 15 μM, respectively. AChE/BACE1/GSK3β-IN-1 has good blood-brain barrier penetrability, suitable bioavailability. AChE/BACE1/GSK3β-IN-1 can be used for the research of Alzheimer's disease (AD). | |||||||||||||||||||||
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Keywords
