2919691-32-8
2919691-32-8
Chemical Structure
HDAC2-IN-1
- CAS No.: 2919691-32-8
- Formula:C22H23ClN4OS
- Molecular Weight:426.96
IUPAC Name: ((2R,4S)-4-(3-chlorophenyl)pyrrolidin-2-yl)(4-(thieno[2,3-c]pyridin-7-yl)piperazin-1-yl)methanone
InChIKey: YMNUWCFQVRYQGA-IEBWSBKVSA-N
SMILES: ClC1=CC([C@@H]2C[C@H](C(N3CCN(CC3)C4=NC=CC5=C4SC=C5)=O)NC2)=CC=C1
Biological Activity: HDAC2-IN-1 (Compound 17) is a brain penetrant, orally active, competitive HDAC2 inhibitor with an IC50 of 0.5 μM[1]. HDAC2-IN-1 also inhibits HDAC1 and HDAC8 with IC50s of 1.61 μM and 0.98 μM, respectively[1].
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HDAC2-IN-1 | HDAC2-IN-1 (Compound 17) is a brain penetrant, orally active, competitive HDAC2 inhibitor with an IC50 of 0.5 μM. HDAC2-IN-1 also inhibits HDAC1 and HDAC8 with IC50s of 1.61 μM and 0.98 μM, respectively. | |||||||||||||||||||||
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References
Keywords
