2922859-30-9
Chemical Structure
CDK2-IN-60
- CAS No.: 2922859-30-9
- Formula:C18H26N6O3
- Molecular Weight:374.44
InChIKey: YVHOVPARADXZIR-NWDGAFQWSA-N
SMILES: O=C(NC(C)(C)C)O[C@H](CC1)C[C@H]1C2=CC(NC(C=C3)=NN(C)C3=O)=NN2
Biological Activity: CDK2-IN-60 is an orally active, ATP-competitive selective CDK2 inhibitor with a Ki of 77 pM. CDK2-IN-60 has high selectivity for both CDK4 and CDK1. CDK2-IN-60 blocks G1/S cell cycle progression to suppress proliferation of CCNE1-amplified tumor cells. CDK2-IN-60 serves as a lead chemical probe for investigating CCNE1-amplified cancers and CDK4/6 inhibitor-resistant HR-positive breast cancer[1].
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CDK2-IN-60 | CDK2-IN-60 is an orally active, ATP-competitive selective CDK2 inhibitor with a Ki of 77 pM. CDK2-IN-60 has high selectivity for both CDK4 and CDK1. CDK2-IN-60 blocks G1/S cell cycle progression to suppress proliferation of CCNE1-amplified tumor cells. CDK2-IN-60 serves as a lead chemical probe for investigating CCNE1-amplified cancers and CDK4/6 inhibitor-resistant HR-positive breast cancer. | |||||||||||||||||||||
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Keywords
