3027565-91-6
3027565-91-6
Chemical Structure
AA3-DLin
- CAS No.: 3027565-91-6
- Formula:C44H78N2O4
- Molecular Weight:699.10
InChIKey: LJCULYBZRITLON-MAZCIEHSSA-N
SMILES: CCCCC/C=C\C/C=C\CCCCCCCC(OCCN1CCN(CC1)CCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O
Biological Activity: AA3-DLin is a biodegradable ionizable cationic lipid (pKa = 5.8). AA3-DLin is used to combine mRNA with lipid nanoparticles (LNPs) for delivery, thereby achieving endosomal escape and cytoplasmic release. AA3-DLin can be used in research on type 2 diabetes, steroid-resistant asthma, lung cancer, ischemic stroke, breast cancer, melanoma, and COVID-19[1][2][3][4][5][6].
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AA3-DLin | 99.0% | AA3-DLin is a biodegradable ionizable cationic lipid (pKa = 5.8). AA3-DLin is used to combine mRNA with lipid nanoparticles (LNPs) for delivery, thereby achieving endosomal escape and cytoplasmic release. AA3-DLin can be used in research on type 2 diabetes, steroid-resistant asthma, lung cancer, ischemic stroke, breast cancer, melanoma, and COVID-19. | ||||||||||||||||||||
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References
- [1]. El-Araby RE, et al. Adiponectin mRNA Conjugated with Lipid Nanoparticles Specifically Targets the Pathogenesis of Type 2 Diabetes. Aging and disease. 2024 May 15;16(2):1059-1079.
- [2]. Huang J, et al. Budesonide-incorporated inhalable lipid nanoparticles for antiTSLP nanobody mRNA delivery to treat steroid-resistant asthma. Nature communications. 2025 Jul 01;16(1):6013.
- [3]. Hu B, et al. Modulating tumor collagen fiber alignment for enhanced lung cancer immunotherapy via inhaled RNA. Nature communications. 2025 Aug 30;16(1):8120. [Content Brief]
- [4]. Gao M, et al. Targeted mRNA Nanoparticles Ameliorate Blood-Brain Barrier Disruption Postischemic Stroke by Modulating Microglia Polarization. ACS nano. 2024 Jan 30;18(4):3260-3275.
- [5]. Li F, et al. mRNA lipid nanoparticle-mediated pyroptosis sensitizes immunologically cold tumors to checkpoint immunotherapy. Nature communications. 2023 Jul 15;14(1):4223. [Content Brief]
- [6]. Li Z, et al. Enzyme-Catalyzed One-Step Synthesis of Ionizable Cationic Lipids for Lipid Nanoparticle-Based mRNA COVID-19 Vaccines. ACS nano. 2022 Nov 22;16(11):18936-18950. [Content Brief]
