3037545-23-3
3037545-23-3
Chemical Structure
Topoisomerase IIα-IN-5
- CAS No.: 3037545-23-3
- Formula:C25H30N2O5
- Molecular Weight:438.52
IUPAC Name: 5-hydroxy-7-(2-hydroxy-3-((2-(piperidin-1-yl)ethyl)amino)propoxy)-2-phenyl-4H-chromen-4-one
InChIKey: WHVFIPDZGJPKHJ-UHFFFAOYSA-N
SMILES: O=C1C=C(OC2=CC(OCC(CNCCN3CCCCC3)O)=CC(O)=C12)C4=CC=CC=C4
Biological Activity: Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629)[1].
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Topoisomerase IIα-IN-5 | Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629). | |||||||||||||||||||||
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References
Keywords
