2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis
  4. Topoisomerase IIα-IN-5

Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629).

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Topoisomerase IIα-IN-5 Chemical Structure

Topoisomerase IIα-IN-5 Chemical Structure

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Topoisomerase IIα-IN-5 Related Antibodies

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Description

Topoisomerase IIα-IN-5 is a topoisomerase II (topo II) α catalytic inhibitor. Topoisomerase IIα-IN-5 intercalates into DNA and binds to the DNA minor groove. Topoisomerase IIα-IN-5 exhibits better efficacy and less genotoxicity than Etoposide (HY-13629)[1].

IC50 & Target[1]

topoisomerase II alpha

 

In Vitro

Topoisomerase IIα-IN-5 (compound 6) (5 μM, 10 μM, and 20 μM; 10 d) inhibits colony formation of DU145 cells[1].
Topoisomerase IIα-IN-5 (1 μM and 10 μM; 72 h) shows antiproliferative against DU145 cells[1].
Topoisomerase IIα-IN-5 has cytotoxicity against DU145, HCT15, and T47D cells with IC50s of 0.13 μM, 9.25 μM, and 0.53 μM, respectively[1].
Topoisomerase IIα-IN-5 (200 μM) interacts with a DNA double helix[1].
Topoisomerase IIα-IN-5 (20 μM; 24 h) induces G2 cell cycle arrest and apoptosis in CRPC cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase IIα-IN-5 Related Antibodies

Western Blot Analysis[1]

Cell Line: CRPC cells
Concentration: 0, 5, 10, and 20 μM
Incubation Time: 0, 8, 16, and 24 hours
Result: Increased the expression of both phosphorylated cdc25c and phosphorylated cdc2.

Apoptosis Analysis[1]

Cell Line: CRPC cells
Concentration: 0, 5, 10, and 20 μM
Incubation Time: 0, 8, 16, and 24 hours
Result: Induced cell cycle arrest at G2 phase.
Induced cell apoptosis.
Molecular Weight

438.52

Formula

C25H30N2O5
SMILES

O=C1C=C(OC2=CC(OCC(CNCCN3CCCCC3)O)=CC(O)=C12)C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topoisomerase IIα-IN-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase IIα-IN-5TopoisomeraseApoptosisInhibitorinhibitorinhibit

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