3044829-88-8
Chemical Structure
AChE/BuChE/MAO-B-IN-2
- CAS No.: 3044829-88-8
- Formula:C19H18FNO3
- Molecular Weight:327.35
IUPAC Name: (E)-2-(3-(4-fluorophenyl)acryloyl)phenyl ethyl(methyl)carbamate
InChIKey: RGWXKYMXEBSYDQ-JLHYYAGUSA-N
SMILES: CCN(C)C(OC1=CC=CC=C1C(/C=C/C2=CC=C(F)C=C2)=O)=O
Biological Activity: AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent AChE/BuChE inhibitor and showed good blood brain barrier (BBB) permeability in vitro with an IC50 value of 5.3 μM, 12.4 μM, 1.9±0.08 μM, for AChE, BuChE, huMAO-B, respectively. AChE/BuChE/MAO-B-IN-2 (compound 4b) can inhibit excess AChE/BuChE in Alzheimer's disease (AD) brain. AChE/BuChE/MAO-B-IN-2 (compound 4b) can be used in anti-Alzheimer's research[1].
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AChE/BuChE/MAO-B-IN-2 | AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent AChE/BuChE inhibitor and showed good blood brain barrier (BBB) permeability in vitro with an IC50 value of 5.3 μM, 12.4 μM, 1.9±0.08 μM, for AChE, BuChE, huMAO-B, respectively. AChE/BuChE/MAO-B-IN-2 (compound 4b) can inhibit excess AChE/BuChE in Alzheimer's disease (AD) brain. AChE/BuChE/MAO-B-IN-2 (compound 4b) can be used in anti-Alzheimer's research. | |||||||||||||||||||||
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Keywords
