2. Neuronal Signaling
  3. Cholinesterase (ChE) Monoamine Oxidase
  4. AChE/BuChE/MAO-B-IN-2

AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent AChE/BuChE inhibitor and showed good blood brain barrier (BBB) permeability in vitro with an IC50 value of 5.3 μM, 12.4 μM, 1.9±0.08 μM, for AChE, BuChE, huMAO-B, respectively. AChE/BuChE/MAO-B-IN-2 (compound 4b) can inhibit excess AChE/BuChE in Alzheimer's disease (AD) brain. AChE/BuChE/MAO-B-IN-2 (compound 4b) can be used in anti-Alzheimer's research.

For research use only. We do not sell to patients.

AChE/BuChE/MAO-B-IN-2 Chemical Structure

AChE/BuChE/MAO-B-IN-2 Chemical Structure

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AChE/BuChE/MAO-B-IN-2 Related Antibodies

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Description

AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent AChE/BuChE inhibitor and showed good blood brain barrier (BBB) permeability in vitro with an IC50 value of 5.3 μM, 12.4 μM, 1.9±0.08 μM, for AChE, BuChE, huMAO-B, respectively. AChE/BuChE/MAO-B-IN-2 (compound 4b) can inhibit excess AChE/BuChE in Alzheimer's disease (AD) brain. AChE/BuChE/MAO-B-IN-2 (compound 4b) can be used in anti-Alzheimer's research[1].

IC50 & Target

AChE

5.3 μM (IC50)

BChE

12.4 μM (IC50)

hMAO-B

1.9 μM (IC50)

In Vitro

AChE/BuChE/MAO-B-IN-2 (5, 10, 20 μmol/L, 2 h) has significant neuroprotective effects against Aβ1-42-induced PC12 cell injury[1].
AChE/BuChE/MAO-B-IN-2 (1 mg/mL for incubate, 0, 0.5, 1, 1.5, 2, 3 h) is stable in artificial gastrointestinal fluid, blood plasma, rat liver microsomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AChE/BuChE/MAO-B-IN-2 Related Antibodies

Cell Viability Assay[1]

Cell Line: PC12 cell
Concentration: 5, 10, 20 μmol/L
Incubation Time: 2 h
Result: Increased the cell viability to 70.9 %, 75.0 % (p < 0.05) and 79.7 % (p < 0.01), respectively, in a dose-dependent manner.
In Vivo

AChE/BuChE/MAO-B-IN-2 (0.0049, 0.0195 and 0.078 μg/mL for treated, 10min) can significantly improve dyskinesia and reaction capacity of AlCl3-induced zebrafish AD model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AlCl3-induced zebrafish AD[1]
Dosage: 0.0049, 0.0195 and 0.078 μg/mL
Administration: incubation
Result: Presented the best distance velocity with 0.0195 μg/mL under the dark condition, with 0.0049 μg/mL under the light condition and with 0.0195 μg/mL under the alternating dark light.
Molecular Weight

327.35

Formula

C19H18FNO3
SMILES

CCN(C)C(OC1=CC=CC=C1C(/C=C/C2=CC=C(F)C=C2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AChE/BuChE/MAO-B-IN-2 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BuChE/MAO-B-IN-2Cholinesterase (ChE)Monoamine OxidaseMAOAlzheimer’s diseasemultifunctional chelatorssite-activated prochelatorzebrafish AD modelInhibitorinhibitorinhibit

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