AChE/BuChE/MAO-B-IN-2
AChE/BuChE/MAO-B-IN-2 (compound 4b) is a potent AChE/BuChE inhibitor and showed good blood brain barrier (BBB) permeability in vitro with an IC50 value of 5.3 μM, 12.4 μM, 1.9±0.08 μM, for AChE, BuChE, huMAO-B, respectively. AChE/BuChE/MAO-B-IN-2 (compound 4b) can inhibit excess AChE/BuChE in Alzheimer's disease (AD) brain. AChE/BuChE/MAO-B-IN-2 (compound 4b) can be used in anti-Alzheimer's research.
For research use only. We do not sell to patients.
- CAS No.: 3044829-88-8
- Formula: C19H18FNO3
- Molecular Weight:327.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AChE 5.3 μM (IC50) |
BChE 12.4 μM (IC50) |
hMAO-B 1.9 μM (IC50) |
AChE/BuChE/MAO-B-IN-2 (5, 10, 20 μmol/L, 2 h) has significant neuroprotective effects against Aβ1-42-induced PC12 cell injury[1].
AChE/BuChE/MAO-B-IN-2 (1 mg/mL for incubate, 0, 0.5, 1, 1.5, 2, 3 h) is stable in artificial gastrointestinal fluid, blood plasma, rat liver microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cell
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Concentration:5, 10, 20 μmol/L
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Incubation Time:2 h
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Result:Increased the cell viability to 70.9 %, 75.0 % (p < 0.05) and 79.7 % (p < 0.01), respectively, in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:AlCl3-induced zebrafish AD[1]
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Dosage:0.0049, 0.0195 and 0.078 μg/mL
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Administration:incubation
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Result:Presented the best distance velocity with 0.0195 μg/mL under the dark condition, with 0.0049 μg/mL under the light condition and with 0.0195 μg/mL under the alternating dark light.
Chemical Information
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CAS No. 3044829-88-8
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Molecular Weight 327.35
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Formula C19H18FNO3
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SMILES
CCN(C)C(OC1=CC=CC=C1C(/C=C/C2=CC=C(F)C=C2)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/BuChE/MAO-B-IN-2 Related Classifications
HY-149090 Related Classifications
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