3066894-28-5
Chemical Structure
FC-14369
- CAS No.: 3066894-28-5
- Formula:C42H34ClF3N8O7
- Molecular Weight:855.22
InChIKey: JRUJAOSECPOZNM-UHFFFAOYSA-N
SMILES: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCNC(COC4=CC=C(CCC5=C(O)N(C6=NC7=C(N6)C=CC(Cl)=C7)N=C5C8=CC=C(C(F)(F)F)C=C8)C=C4)=O)=CC=C3)=O)=O
Biological Activity: FC-14369 is a PROTAC degrader targeting the HIV-1 Nef protein, with a DC50 value of 160 nM. Through its bifunctional structure, FC-14369 binds to Nef and the Cereblon E3 ubiquitin ligase, induces Nef ubiquitination and proteasomal degradation, restores the expression of cell-surface CD4 and MHC-I, and inhibits HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS. FC-14369 is applicable to studies related to HIV-1 infection[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
FC-14369 | 97.85% | FC-14369 is a PROTAC degrader targeting the HIV-1 Nef protein, with a DC50 value of 160 nM. Through its bifunctional structure, FC-14369 binds to Nef and the Cereblon E3 ubiquitin ligase, induces Nef ubiquitination and proteasomal degradation, restores the expression of cell-surface CD4 and MHC-I, and inhibits HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS. FC-14369 is applicable to studies related to HIV-1 infection. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Keywords
