3097325-25-9
3097325-25-9
Chemical Structure
PKMYT1-IN-11
- CAS No.: 3097325-25-9
- Formula:C18H16F4N4O2
- Molecular Weight:396.34
InChIKey: JVKUVKQDZRWVFJ-UHFFFAOYSA-N
SMILES: NC1=C(C(N)=O)C2=C([N@@]1[C@@]3=C(C)C(O)=C(F)C=C3C)N=C(C)C(C(F)(F)F)=C2
Biological Activity: PKMYT1-IN-11 (Example 1) is a PKMYT1 inhibitor with an IC50 of 4.49 nM. PKMYT1-IN-11 inhibits the proliferation of HCC1569 cells. When combined with Gemcitabine (HY-17026), PKMYT1-IN-11 shows a significant anti-tumor effect in the OVCAR3 xenograft mouse model. PKMYT1-IN-11 can be used for the study of various cancers such as breast cancer and ovarian cancer[1].
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PKMYT1-IN-11 | PKMYT1-IN-11 (Example 1) is a PKMYT1 inhibitor with an IC50 of 4.49 nM. PKMYT1-IN-11 inhibits the proliferation of HCC1569 cells. When combined with Gemcitabine (HY-17026), PKMYT1-IN-11 shows a significant anti-tumor effect in the OVCAR3 xenograft mouse model. PKMYT1-IN-11 can be used for the study of various cancers such as breast cancer and ovarian cancer. | |||||||||||||||||||||
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References
Keywords
