3124773-51-6
Chemical Structure
HDAC-IN-98
- CAS No.: 3124773-51-6
- Formula:C24H21N3O4
- Molecular Weight:415.44
InChIKey: QRQCTUOLOHTZAD-XYOKQWHBSA-N
SMILES: O=C(/C=C/C1=CC2=C(C=C1)OCO2)NCC3=CC=C(C=C3)C(NC4=CC=CC=C4N)=O
Biological Activity: HDAC-IN-98 is a HDAC1, HDAC2, HDAC3 inhibitor (one of the most selective class I HDAC inhibitors) with human IC50 values of 41.2 nM, 52.5 nM, and 74.3 nM respectively. HDAC-IN-98 induces H3K9 acetylation, p21 upregulation, G2/M arrest, cell apoptosis, has strong antiproliferative effects in colorectal cancer cells, low toxicity in healthy colon epithelium, modulates short-term in vitro effects via autophagy, and shows strong antitumor efficacy in vivo in the chorioallantoic membrane model (CAM) assay. HDAC-IN-98 can be used for the research of colorectal cancer[1].
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HDAC-IN-98 | 98.36% | HDAC-IN-98 is a HDAC1, HDAC2, HDAC3 inhibitor (one of the most selective class I HDAC inhibitors) with human IC50 values of 41.2 nM, 52.5 nM, and 74.3 nM respectively. HDAC-IN-98 induces H3K9 acetylation, p21 upregulation, G2/M arrest, cell apoptosis, has strong antiproliferative effects in colorectal cancer cells, low toxicity in healthy colon epithelium, modulates short-term in vitro effects via autophagy, and shows strong antitumor efficacy in vivo in the chorioallantoic membrane model (CAM) assay. HDAC-IN-98 can be used for the research of colorectal cancer. | ||||||||||||||||||||
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Keywords
