66004-77-1
Chemical Structure
ddCTP
- CAS No.: 66004-77-1
- Formula:C9H16N3O12P3
- Molecular Weight:451.16
IUPAC Name: ((2S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
InChIKey: ARLKCWCREKRROD-POYBYMJQSA-N
SMILES: O=[P](O[P](O[P](O)(O)=O)(O)=O)(O)OC[C@@H]1CC[C@H](N2C(N=C(N)C=C2)=O)O1
Biological Activity: ddCTP is a type of chain-terminating deoxynucleotide. ddCTP can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication[1][2][3].
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ddCTP | ddCTP is a type of chain-terminating deoxynucleotide. ddCTP can be incorporated into the extension primer chain that lacks the 3'-hydroxyl group, thereby terminating primer extension, viral genome replication, and DNA synthesis. ddCTP can distinguish almost identical RNA through distinguishable extension products in primer extension inhibition experiments. ddCTP is the active metabolite of Zalcitabine (HY-17392), which can competitively inhibit HIV reverse transcriptase, terminate the synthesis of viral DNA chains, and thereby inhibit HIV replication. | |||||||||||||||||||||
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[1]. Nilsen TW. Poisoned primer extension. Cold Spring Harb Protoc. 2015 Jan 5;2015(1):pdb.prot080986.
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[2]. Adkins JC, et al. An update of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of HIV infection. Drugs. 1997 Jun;53(6):1054-80.
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[3]. Z G Chidgeavadze, et al. 3'-Fluoro-2',3'-dideoxyribonucleoside 5'-triphosphates: terminators of DNA synthesis. FEBS Lett. 1985 Apr 22;183(2):275-8.
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Keywords
