83982-78-9
83982-78-9
Chemical Structure
Enoximone sulfoxide
Synonym(s): MDL 19438
- CAS No.: 83982-78-9
- Formula:C12H12N2O3S
- Molecular Weight:264.30
InChIKey: XHRYEIRXTWSXAE-UHFFFAOYSA-N
SMILES: O=C1NC(C(C2=CC=C(S(C)=O)C=C2)=O)=C(C)N1
Biological Activity: Enoximone sulfoxide (MDL 19438) is the primary sulfoxide metabolite of Enoximone (HY-B1639). Enoximone sulfoxide is also a cardiotonic agent with positive inotropic, positive chronotropic, and vasodilatory activities. Enoximone sulfoxide can be used in the research of congestive heart failure[1][2][3][4].
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Enoximone sulfoxide | Enoximone sulfoxide (MDL 19438) is the primary sulfoxide metabolite of Enoximone (HY-B1639). Enoximone sulfoxide is also a cardiotonic agent with positive inotropic, positive chronotropic, and vasodilatory activities. Enoximone sulfoxide can be used in the research of congestive heart failure. | |||||||||||||||||||||
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References
- [1]. Walter B A, et al. An Automated Method for the Determination of Enoximone and Its Major Sulfoxide Metabolite in Plasma Using Robotic Technology–High Performance Liquid Chromatography. Journal of Liquid Chromatography, 1986, 9(14): 3133-3155.
- [2]. Uretsky BF, et al. Acute hemodynamic effect of oral MDL 17,043 in severe congestive heart failure. The American journal of cardiology. 1984 Aug 01;54(3):357-62.
- [3]. Dage RC, et al. Pharmacology and pharmacokinetics of enoximone. Cardiology. 1990;77 Suppl 3:2-13; discussion 27-33. [Content Brief]
- [4]. Ruder MA, et al. Disposition kinetics of orally administered enoximone in patients with moderate to severe heart failure. Journal of clinical pharmacology. 1991 Aug;31(8):702-8.
