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Cat. No.: HY-187722

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Enoximone sulfoxide

Name: Enoximone sulfoxide
Brand: MedChemExpress
SKU: HY-187722
Availability: PreOrder

(Synonyms: MDL 19438)

Enoximone sulfoxide (MDL 19438) is the primary sulfoxide metabolite of Enoximone (HY-B1639). Enoximone sulfoxide is also a cardiotonic agent with positive inotropic, positive chronotropic, and vasodilatory activities. Enoximone sulfoxide can be used in the research of congestive heart failure.

For research use only. We do not sell to patients.

CAS No.: 83982-78-9
Formula: C₁₂H₁₂N₂O₃S
Molecular Weight:264.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Enoximone sulfoxide Chemical Structure

CAS No.: 83982-78-9

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

In Vitro

Enoximone sulfoxide (MDL 19438) (5 μM; incubated for 5-120 min) has the effect of being reduced to Enoximone in the 9000 g supernatant of rat liver and kidney^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Enoximone sulfoxide (3 mg/kg; i.v.; single injection) exhibits positive inotropic activity that is 0.14 times as potent as enoximone but has a 13-fold longer duration of action, plus vasodilator activity, in anaesthetized dogs^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

unspecified (anaesthetized)^[3]
Dosage:

3 mg/kg
Administration:

i.v.; single injection
Result:

Increased cardiac contractile force from baseline, with a duration of inotropic action 13 times longer than that of enoximone.
Demonstrated inotropic activity 0.14 times as potent as enoximone.
Exhibited vasodilator activity.

Chemical Information

CAS No. 83982-78-9
Molecular Weight 264.30
Formula C₁₂H₁₂N₂O₃S
SMILES

O=C1NC(C(C2=CC=C(S(C)=O)C=C2)=O)=C(C)N1
Synonyms

MDL 19438
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Walter B A, et al. An Automated Method for the Determination of Enoximone and Its Major Sulfoxide Metabolite in Plasma Using Robotic Technology–High Performance Liquid Chromatography. Journal of Liquid Chromatography, 1986, 9(14): 3133-3155.

[2]. Uretsky BF, et al. Acute hemodynamic effect of oral MDL 17,043 in severe congestive heart failure. The American journal of cardiology. 1984 Aug 01;54(3):357-62.

[3]. Dage RC, et al. Pharmacology and pharmacokinetics of enoximone. Cardiology. 1990;77 Suppl 3:2-13; discussion 27-33. [Content Brief]

[4]. Ruder MA, et al. Disposition kinetics of orally administered enoximone in patients with moderate to severe heart failure. Journal of clinical pharmacology. 1991 Aug;31(8):702-8.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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