84297-49-4
Chemical Structure
1,2,4,6-Tetra-O-galloyl-β-D-glucose
- CAS No.: 84297-49-4
- Formula:C34H28O22
- Molecular Weight:788.57
InChIKey: YXZYFHXWEOAXLF-UGAZNADUSA-N
SMILES: O=C(C1=CC(O)=C(C(O)=C1)O)O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)OC(C3=CC(O)=C(C(O)=C3)O)=O)COC(C4=CC(O)=C(C(O)=C4)O)=O)OC(C5=CC(O)=C(C(O)=C5)O)=O
Biological Activity: 1,2,4,6-Tetra-O-galloyl-β-D-glucose is an acetylcholinesterase inhibitor with an IC50 of 1.5 μM against human targets. 1,2,4,6-Tetra-O-galloyl-β-D-glucose inhibits the aggregation of amyloid-β. 1,2,4,6-Tetra-O-galloyl-β-D-glucose exhibits anti-herpesvirus activity against both HSV-1 and HSV-2 in vitro. 1,2,4,6-Tetra-O-galloyl-β-D-glucose possesses superoxide dismutase-like antioxidant activity, and also inhibits tyrosinase and hyaluronidase. 1,2,4,6-Tetra-O-galloyl-β-D-glucose can be used in studies related to Alzheimer's disease, herpesvirus infection and antioxidation[1][2][3].
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1,2,4,6-Tetra-O-galloyl-β-D-glucose | 1,2,4,6-Tetra-O-galloyl-β-D-glucose is an acetylcholinesterase inhibitor with an IC50 of 1.5 μM against human targets. 1,2,4,6-Tetra-O-galloyl-β-D-glucose inhibits the aggregation of amyloid-β. 1,2,4,6-Tetra-O-galloyl-β-D-glucose exhibits anti-herpesvirus activity against both HSV-1 and HSV-2 in vitro. 1,2,4,6-Tetra-O-galloyl-β-D-glucose possesses superoxide dismutase-like antioxidant activity, and also inhibits tyrosinase and hyaluronidase. 1,2,4,6-Tetra-O-galloyl-β-D-glucose can be used in studies related to Alzheimer's disease, herpesvirus infection and antioxidation. | |||||||||||||||||||||
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References
- [1]. Iwaoka Y, et al. Polyphenols from Trapa bispinosa Roxb. pericarp extract with inhibitory activities against amyloid‑β aggregation and acetylcholinesterase. Results in Chemistry, 2026, 28:103617.
- [2]. Xiang Y, et al. In vitro anti-herpes simplex virus activity of 1,2,4,6-tetra-O-galloyl-β-D-glucose from Phyllanthus emblica L. (Euphorbiaceae). Phytotherapy research : PTR. 2011 Jul;25(7):975-82. [Content Brief]
- [3]. Sugimoto K, et al. Hydrolyzable Tannins as Antioxidants in the Leaf Extract of Eucalyptus globulus Possessing Tyrosinase and Hyaluronidase Inhibitory Activities. Food Science and Technology Research, 2009, 15(3): 331‑336.
