94724-12-6
Chemical Structure
Compound 48/80
Synonym(s): Poly-p-methoxyphenethylmethylamine
- CAS No.: 94724-12-6
- Formula:C32H45N3O3
- Molecular Weight:519.72
IUPAC Name: 2,2'-(((2-methoxy-5-(2-(methylamino)ethyl)-1,3-phenylene)bis(methylene))bis(4-methoxy-3,1-phenylene))bis(N-methylethan-1-amine)
InChIKey: DXEVTBAWIGXNAW-UHFFFAOYSA-N
SMILES: CNCCC1=CC(CC2=CC(CCNC)=CC=C2OC)=C(OC)C(CC3=CC(CCNC)=CC=C3OC)=C1
Biological Activity: Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2].
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Compound 48/80 | 99.98% | Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways. | ||||||||||||||||||||
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- [1]. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. [Content Brief]
- [2]. Wang YH, Taché Y, Harris AG, Kreutner W, Daly AF, Wei JY. Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique. Allergy. 2005;60(1):117-124. [Content Brief]
Keywords
