L-Tyrosine
Based on 9 publication(s) in Google Scholar
L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.73%
- CAS. Nr.: 60-18-4
- Formel: C9H11NO3
- Molecular Weight:181.19
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Tyrosine
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Microbiome. 2019 Mar 20;7(1):43. [Abstract]
- Acta Pharm Sin B. 2024 Aug;14(8):3493-3512. [Abstract]
- Laser Photon Rev. 2025 Jun 06.
- Biometals. 2026 Jun;39(3):1167-1189. [Abstract]
- J Sep Sci. 2026 Apr;49(4):e70402. [Abstract]
- Amino Acids. 2024 Sep 18;56(1):56. [Abstract]
- Physiol Rep. 2025 Aug;13(16):e70465. [Abstract]
- SSRN. 2025 Aug 13.
Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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Microbial Metabolite |
Human Endogenous Metabolite |
L-Tyrosine inhibits citrate synthase activity in the posterior cortex (2.0 and 4.0 mM), malate dehydrogenase is not altered by L-Tyrosine and succinate dehydrogenase is increased in the posterior cortex (0.1-4.0 mM), hippocampus (1.0-4.0 mM), striatum (4.0 mM) and liver (0.1-4.0 mM). When complex I activity is analyzed, inhibition is observed in hippocampus (4.0 mM). In addition to inhibition in the hippocampus, complex II also is inhibited in the posterior cortex (0.1-4.0 mM) and liver (1.0, 2.0 and 4.0 mM). For complex II–III, activity is not altered by L-Tyrosine, and complex IV activity has decreased in the posterior cortex (1.0-4.0 mM) following treatment with L-Tyrosine[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 60-18-4
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Appearance Solid
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Molecular Weight 181.19
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Formel C9H11NO3
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Color White to off-white
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SMILES
N[C@@H](CC1=CC=C(C=C1)O)C(O)=O
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Synonyms
Tyrosine
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (9)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Microbiome
Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. [Abstract]2019 Mar 20;7(1):43. PMID: 30890187 -
Acta Pharm Sin B
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis. [Abstract]2024 Aug;14(8):3493-3512. PMID: 39220878 -
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Biometals
Aromatic amino acid metabolism shapes autophagy-mediated adaptation to iron deprivation in glioblastoma cells. [Abstract]2026 Jun;39(3):1167-1189. PMID: 41925978 -
J Sep Sci
Oriented Immobilization Coupled With Ligand Fishing Strategy for Rapid Discovery of Direct HMGB1 Inhibitors in Taxus wallichiana var. mairei. [Abstract]2026 Apr;49(4):e70402. PMID: 41906428 -
Amino Acids
Identification of amino acids metabolomic profiling in human plasma distinguishes lupus nephritis from systemic lupus erythematosus. [Abstract]2024 Sep 18;56(1):56. PMID: 39292313 -
Physiol Rep
Metabolic shifts in plasma amino acids and related metabolites in response to SGLT2 inhibition and hyperglycemia in type 1 diabetes. [Abstract]2025 Aug;13(16):e70465. PMID: 40842430 -
Lösungsmittel & Löslichkeit
1M HCl : 50 mg/mL (275.95 mM; Need ultrasonic)
0.1 M HCl : 25 mg/mL (137.98 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Protokoll
Posterior cortex, hippocampus, striatum and liver supernatants of 30-day-old rats are pre-incubated for 30 min at 30°C in the presence of L-Tyrosine (Tyr) at final concentrations ranging from 0.1, 1.0, 2.0 or 4.0 mM, and the activities of citrate synthase, malate dehydrogenase and respiratory chain complexes I, II, II–III and IV are evaluated[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
The equivalent of 500 mg/kg body weight of free L-Tyrosine is intraperitoneally administered in 30-day-old rats. Controls receive in saline solution. About 1 h after injections, rats are killed by decapitation without anesthesia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.1 M HCl / 1M HCl | 1 mM | 5.5190 mL | 27.5952 mL | 55.1904 mL | 137.9760 mL |
| 5 mM | 1.1038 mL | 5.5190 mL | 11.0381 mL | 27.5952 mL | |
| 10 mM | 0.5519 mL | 2.7595 mL | 5.5190 mL | 13.7976 mL | |
| 15 mM | 0.3679 mL | 1.8397 mL | 3.6794 mL | 9.1984 mL | |
| 20 mM | 0.2760 mL | 1.3798 mL | 2.7595 mL | 6.8988 mL | |
| 25 mM | 0.2208 mL | 1.1038 mL | 2.2076 mL | 5.5190 mL | |
| 30 mM | 0.1840 mL | 0.9198 mL | 1.8397 mL | 4.5992 mL | |
| 40 mM | 0.1380 mL | 0.6899 mL | 1.3798 mL | 3.4494 mL | |
| 50 mM | 0.1104 mL | 0.5519 mL | 1.1038 mL | 2.7595 mL | |
| 60 mM | 0.0920 mL | 0.4599 mL | 0.9198 mL | 2.2996 mL | |
| 80 mM | 0.0690 mL | 0.3449 mL | 0.6899 mL | 1.7247 mL | |
| 100 mM | 0.0552 mL | 0.2760 mL | 0.5519 mL | 1.3798 mL |
L-Tyrosine Related Classifications
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