Sstr3 - somatostatin receptor 3 Gene

Also Known as SSTR; Smstr28

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171044

About Sstr3

Primary_assembly 7: 110,092,575-110,099,769 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 251 orthologues, 14 paralogues and is associated with 5 phenotypes. Biased expression in Brain (RPKM 43.2), Thymus (RPKM 37.4) and 4 other tissues.

Summary

Predicted to enable G protein-coupled receptor activity; neuropeptide binding activity; and signaling receptor binding activity. Involved in several processes, including brain development; cellular response to lipid; and spermatogenesis. Located in cytoplasm and plasma membrane. Orthologous to human SSTR3 (Somatostatin Receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Sstr3 Products (1)

mRNA Protein Name
NM_133522.2 NP_598206.1 somatostatin receptor type 3

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
9564833 RGD
involved in cellular response to glucocorticoid stimulus IEP
IEP: Inferred from expression pattern
14512709 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
9166718 RGD
involved in forebrain development IEP
IEP: Inferred from expression pattern
10805921 RGD
involved in response to starvation IEP
IEP: Inferred from expression pattern
7956902 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
9421433 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sstr3 Protein Structure

7tm_GPCRs

7tm_GPCRs: cl28897 (45 - 332)

7tm_GPCRs

7tm_GPCRs: cd14964 (47 - 71)

7tm_GPCRs

7tm_GPCRs: cd14964 (80 - 101)

7tm_GPCRs

7tm_GPCRs: cd14964 (117 - 139)

7tm_GPCRs

7tm_GPCRs: cd14964 (162 - 178)

7tm_GPCRs

7tm_GPCRs: cd14964 (204 - 227)

7tm_GPCRs

7tm_GPCRs: cd14964 (264 - 286)

7tm_GPCRs

7tm_GPCRs: cd14964 (300 - 325)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
Protein Preferred Names Protein Names

somatostatin receptor type 3

  • SS-3-R

  • SS3-R

  • SS3R

  • SSR-28

  • somatostatin receptor 28

  • somatostatin receptor subtype 3

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-P0036 Octreotide Agonist 99.96% Unkown
HY-P0036B Octreotide pamoate Agonist / Unkown

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P0024 Veldoreotide Activator / Phase 2

Pre-clinical Phase

Bioactive Molecules (12)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P1932 Cortistatin-14 99.98% Unkown
HY-P1203 BIM-23056 Antagonist 99.98% Unkown
HY-P0024A Veldoreotide TFA Agonist 98.97% Unkown
HY-P4452 PRL 2915 Antagonist 99.92% Unkown
HY-P3618 Cortistatin-29 (reduced) 98.12% Unkown
HY-123335 L-796778 Agonist 98.00% Unkown
HY-P4469 PRL 3195 Antagonist / Unkown
HY-177493 SSTR3 Agonist-1 Agonist / Unkown
HY-123460 BN-81674 Antagonist / Unkown
HY-P2150 Cortistatin-29 (rat) / Unkown
HY-P1203A BIM-23056 TFA Antagonist / Unkown
HY-177493A SSTR3 agonist-1 TFA Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sstr3 NCBI NCBI:6753