ZSCAN4 - zinc finger and SCAN domain containing 4 Gene

Also Known as ZNF494

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 201516

About ZSCAN4

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:57,651,476-57,679,152 (from NCBI)

This gene has 1 transcript (splice variant), 31 orthologues and 31 paralogues. Low expression observed in reference dataset.

Summary

The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]

ZSCAN4 Products (2)

mRNA Protein Name
NM_001384833.1 NP_001371762.1 zinc finger and SCAN domain-containing protein 4
NM_152677.4 NP_689890.1 zinc finger and SCAN domain-containing protein 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZSCAN4 Protein Structure

SCAN

SCAN: SCAN domain (40 - 129)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (326 - 349)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (354 - 379)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (382 - 405)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 433 a.a.
Protein Preferred Names Protein Names

zinc finger and SCAN domain-containing protein 4

  • zinc finger protein 494

ZSCAN4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
ZSCAN4 Q8NAM6 CIB3 Homo sapiens Q96Q77
Validated Y2H
32296183
Intra
ZSCAN4 Q8NAM6 LAMTOR3 Homo sapiens Q9UHA4
Validated Y2H
32296183
Intra
ZSCAN4 Q8NAM6 FAM110A Homo sapiens Q9BQ89
Validated Y2H
32296183
Intra
ZSCAN4 Q8NAM6 PARD6B Homo sapiens Q9BYG5
Validated Y2H
32296183
Intra
ZSCAN4 Q8NAM6 TRAF3 Homo sapiens Q13114
Y2H Prey Pooling
32296183
Intra
ZSCAN4 Q8NAM6 TRAF3 Homo sapiens Q13114
Y2H Array
32296183
Intra
ZSCAN4 Q8NAM6 KAT5 Homo sapiens Q92993
Validated Y2H
32296183
Intra
ZSCAN4 Q8NAM6 EXOC8 Homo sapiens Q8IYI6
Y2H Prey Pooling
32296183
Intra
ZSCAN4 Q8NAM6 EXOC8 Homo sapiens Q8IYI6
Y2H Array
32296183
Intra
ZSCAN4 Q8NAM6 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Facioscapulohumeral Muscular Dystrophy 1

  • Facioscapulohumeral Muscular Dystrophy

  • Fshd

  • Landouzy-Dejerine Muscular Dystrophy

  • Muscular Dystrophy, Facioscapulohumeral

  • FSHD1

  • Fshd1a

  • Muscular Dystrophy, Facioscapulohumeral, Type 1a

  • Facioscapulohumeral Muscular Dystrophy Type 1a

  • Fsh Muscular Dystrophy

  • Facioscapulohumeral Muscular Dystrophy 1a

  • Facioscapulohumeral Atrophy

  • Facioscapulohumeral Myopathy

  • Muscular Dystrophy, Facioscapulohumeral, Type 1

  • Facioscapulohumeral Muscular Dystrophy Type 1

  • Landouzy Dejerine Muscular Dystrophy

  • Muscular Dystrophy, Landouzy-Dejerine

  • Fshmd1a

  • Facio-Scapulo-Humeral Dystrophy

  • Facioscapulohumeral Type Progressive Muscular Dystrophy

  • Facioscapuloperoneal Muscular Dystrophy

  • Facioscapulohumeral Dystrophy

  • Fsh Dystrophy

  • Landouzy-Dejerine Dystrophy

  • Landouzy-Dejerine Myopathy

  • Fmd

  • Facioscapulohumeral Muscular Dystrophy-1a

  • Muscular Dystrophy Facioscapulohumeral

  • Dystrophy, Muscular, Facioscapulohumeral

  • Dystrophy, Muscular, Facioscapulohumeral, Type 1

  • Landouzy-Dejerine Disease

  • Landouzy-Déjerine Atrophy

  • Facioscapulohumeral Muscle Dystrophy

  • Fmd - [Facioscapulohumeral Muscular Dystrophy]

  • Fsh - [Facioscapulohumeral Muscular Dystrophy]

  • Fshd - [Facioscapulohumeral Muscular Dystrophy]

  • Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy

  • Landouzy-Déjérine Muscular Dystrophy
Facioscapulohumeral Muscular Dystrophy 2, Digenic

  • Facioscapulohumeral Muscular Dystrophy 2

  • FSHD2

  • Fshd1b

  • Facioscapulohumeral Muscular Dystrophy 1b

  • Fshd2, Digenic

  • Muscular Dystrophy, Facioscapulohumeral, Type 2

  • Muscular Dystrophy, Facioscapulohumeral, Type 1b

  • Fascioscapulohumeral Muscular Dystrophy 2, Digenic

  • Facioscapulohumeral Muscular Dystrophy Type 2

  • Digenic Facioscapulohumeral Muscular Dystrophy

  • Digenic Fshd2

  • Facioscapulohumeral Muscular Dystrophy Type 1b

  • Dystrophy, Muscular, Facioscapulohumeral, Type 2
Digenic Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS16202 ZSCAN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZSCAN4 RGD RGD:1563625
Bos taurus ZSCAN4 VGNC VGNC:52275
Macaca mulatta ZSCAN4 VGNC VGNC:79403
Others ZSCAN4 NCBI