HDAC3-IN-8
HDAC3-IN-8 is a selective inhibitor targeting HDAC1, HDAC2 and HDAC3, with IC50 values of 3.52 nM for HDAC1, 15.14 nM for HDAC2 and 0.38 nM for HDAC3. HDAC3-IN-8 shows high selectivity for HDAC3 and exerts its effect by inhibiting histone deacetylase activity. HDAC3-IN-8 can be used to construct HDAC3-targeted PROTAC degrader (HY-181767) and is suitable for the research of acute myeloid leukemia (AML).
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- CAS. Nr.: 2763368-90-5
- Formel: C20H21N3O3
- Molecular Weight:351.40
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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HDAC3 0.38 nM (IC50) |
HDAC1 3.52 nM (IC50) |
HDAC2 15.14 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| MV4-11 | IC50 |
36.8 nM
Compound: 11i
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Antiproliferative activity against human MV4-11 AML cells assessed as cell viability measured after 48 hrs by by multiplate reader method
Antiproliferative activity against human MV4-11 AML cells assessed as cell viability measured after 48 hrs by by multiplate reader method
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[PMID: 34942071] |
Chemical Information
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CAS. Nr. 2763368-90-5
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Molecular Weight 351.40
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Formel C20H21N3O3
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SMILES
O=C(C1=CC2=CC=CC=C2O1)NCC3=CC=C(C(NNCCC)=O)C=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC3-IN-8 Related Classifications
HY-181768 Related Classifications
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