st-Ht31
st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage.
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- CAS. Nr.: 188425-80-1
- Formel: C129H217N29O39
- Molecular Weight:2798.32
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
st-Ht31 (5 μM; 2 h) enhances cholesterol/phospholipid efflux in BHK cells and RAW macrophages[1].
st-Ht31 (10μM; 24 h) reverses foam cell formation and restores metabolic health of macrophage[1].
st-Ht31 (20 μM; 20 min) abolishes the cAMP inhibition of PMA-induced ERK1/2 activation n HEK293T cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293T cells
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Concentration:20 µM
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Incubation Time:20 min
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Result:Abolished the cAMP inhibition of PMA-induced ERK1/2 activation.
Chemical Information
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CAS. Nr. 188425-80-1
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Molecular Weight 2798.32
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Formel C129H217N29O39
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Sequence
{N-Stearate}-Asp-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr
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Sequence Shortening
{N-Stearate}-DLIEEAASRIVDAVIEQVKAAGAY
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Ma L, et al. Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem. 2011 Feb 4;286(5):3370-8. [Content Brief]
[2]. Rahamim Ben-Navi L, et al. A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa. Sci Rep. 2016 Nov 30;6:37922. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
st-Ht31 Related Classifications
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