188425-80-1
Chemical Structure
st-Ht31
- CAS No.: 188425-80-1
- Formula:C129H217N29O39
- Molecular Weight:2798.32
SMILES: [C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(O)=O)=O)C)=O)=O)C)=O)C)=O)CCCCN)=O)[C@@H](C)C)=O)CCC(N)=O)=O)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CCCCCCCCCCCCCCCCC)=O)CC(O)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)C)=O)C)=O)CO)=O)CCCNC(=N)N)=O)[C@H](CC)C)=O)C(C)C)=O)CC(O)=O)=O)C)=O)C(C)C)=O)[C@H](CC)C)=O)CCC(O)=O
Biological Activity: st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage[1][2].
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st-Ht31 | st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage. | |||||||||||||||||||||
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References
- [1]. Ma L, et al. Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem. 2011 Feb 4;286(5):3370-8. [Content Brief]
- [2]. Rahamim Ben-Navi L, et al. A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa. Sci Rep. 2016 Nov 30;6:37922. [Content Brief]
