st-Ht31 

st-Ht31 is a membrane-permeable peptide inhibitor of protein kinase A (PKA) anchoring. st-Ht31 induces robust cholesterol/phospholipid efflux. st-Ht31 completely reverses foam cell formation and restores the metabolic health of macrophage^[1][2].

st-Ht31 (5 µM; 2 h) enhances cholesterol/phospholipid efflux in BHK cells and RAW macrophages^[1].
st-Ht31 (10µM; 24 h) reverses foam cell formation and restores metabolic health of macrophage^[1].
st-Ht31 (20 µM; 20 min) abolishes the cAMP inhibition of PMA-induced ERK1/2 activation n HEK293T cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2798.32

C₁₂₉H₂₁₇N₂₉O₃₉

188425-80-1

{N-Stearate}-Leu-Ile-Glu-Glu-Ala-Ala-Ser-Arg-Ile-Val-Asp-Ala-Val-Ile-Glu-Gln-Val-Lys-Ala-Ala-Gly-Ala-Tyr

{N-Stearate}-LIEEAASRIVDAVIEQVKAAGAY

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ma L, et al. Ht31, a protein kinase A anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ATP-binding cassette transporter A1. J Biol Chem. 2011 Feb 4;286(5):3370-8.  [Content Brief]

  [2]. Rahamim Ben-Navi L, et al. A-Kinase Anchoring Protein 4 (AKAP4) is an ERK1/2 substrate and a switch molecule between cAMP/PKA and PKC/ERK1/2 in human spermatozoa. Sci Rep. 2016 Nov 30;6:37922.  [Content Brief]