METTL3 - methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Gene

Also Known as M6A; IME4; Spo8; MT-A70; hMETTL3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 56339

About METTL3

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,498,138-21,511,340 (from NCBI)

This gene has 14 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in lymph node (RPKM 23.5), testis (RPKM 22.1) and 25 other tissues.

Summary

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]

METTL3 Products (1)

mRNA	Protein	Name
NM_019852.5	NP_062826.2	N6-adenosine-methyltransferase catalytic subunit

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables RNA methyltransferase activity	IDA IDA: Inferred from direct assay	25799998	GOA
enables S-adenosyl-L-methionine binding	IDA IDA: Inferred from direct assay	27281194	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	27281194	GOA
enables mRNA m(6)A methyltransferase activity	IDA IDA: Inferred from direct assay	24316715	GOA
enables mRNA m(6)A methyltransferase activity	IMP IMP: Inferred from mutant phenotype	9409616	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24316715	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	27373337	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	27281194	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	28297716	GOA
involved in RNA methylation	IMP IMP: Inferred from mutant phenotype	9409616	GOA
involved in cellular response to UV	IDA IDA: Inferred from direct assay	28297716	GOA
involved in dosage compensation by inactivation of X chromosome	IDA IDA: Inferred from direct assay	27602518	GOA
involved in mRNA modification	IDA IDA: Inferred from direct assay	27373337	GOA
involved in mRNA processing	IDA IDA: Inferred from direct assay	24316715	GOA
involved in mRNA processing	IMP IMP: Inferred from mutant phenotype	22575960	GOA
involved in mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	25719671	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	30559377	GOA
involved in positive regulation of cap-independent translational initiation	IMP IMP: Inferred from mutant phenotype	26593424	GOA
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	30559377	GOA
involved in primary miRNA processing	IDA IDA: Inferred from direct assay	25799998	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of RNA N6-methyladenosine methyltransferase complex	IDA IDA: Inferred from direct assay	24316715	GOA
part of RNA N6-methyladenosine methyltransferase complex	IPI IPI: Inferred from physical interaction	29507755	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	24407421	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9409616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL3 Protein Structure

MT-A70

0
100
200
300
400
500
580 a.a.

Protein Preferred Names	Protein Names
N6-adenosine-methyltransferase catalytic subunit	N6-adenosine-methyltransferase 70 kDa subunit

METTL3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	METTL3	Q86U44	METTL14	Homo sapiens	Q9HCE5	Anti Tag CoIP	29507755
Intra	METTL3	Q86U44	METTL14	Homo sapiens	Q9HCE5	X-Ray Diffraction	27373337
Intra	METTL3	Q86U44	METTL14	Homo sapiens	Q9HCE5	Radiolabeled Methyl	27373337
Intra	METTL3	Q86U44	METTL14	Homo sapiens	Q9HCE5	Anti Tag CoIP	26496610

Cross: Cross-species interaction Intra: Intraspecies interaction

METTL3 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P80223	METTL3 Antibody (YA294)	WB, IHC-P, FC	Human, Mouse, Rat
HY-P86598	METTL3 Antibody (YA6290)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Bladder Urothelial Carcinoma	Bladder Transitional Cell Carcinoma Transitional Cell Carcinoma Of Bladder Transitional Cell Carcinoma Of The Bladder Urinary Bladder Urothelial Carcinoma Urothelial Bladder Carcinoma Carcinoma Transitional Cell Bladder Tcc - [Transitional Cell Carcinoma] Of Bladder
Hepatoblastoma
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Ocular Melanoma	Intraocular Melanoma Uveal Melanoma Eye Melanoma Melanoma Of Eye Melanoma Of The Uvea Malignant Melanoma Of Eye
Retinitis Pigmentosa 11	RP11 Retinitis Pigmentosa-11 Retinitis Pigmentosa, Type 11
Cervix Carcinoma	Cancer Of Cervix Carcinoma Of Cervix Carcinoma Cervix Uteri Carcinoma Of The Cervix Uteri
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-156677	STC-15	Inhibitor	99.90%	Phase 2

Pre-clinical Phase

Bioactive Molecules (30)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-134836	STM2457	Inhibitor	99.57%	Unkown
HY-156773	STM3006	Inhibitor	98.71%	Unkown
HY-160415A	WD6305 TFA	Degrader	99.81%	Unkown
HY-115717	UZH2	Inhibitor	98.91%	Unkown
HY-W037893	CHMA1004 dihydrochloride	Activator	99.38%	Unkown
HY-160415	WD6305	Degrader	98.98%	Unkown
HY-P10387	RSM3	Inhibitor	95.73%	Unkown
HY-158404	METTL3-IN-8	Inhibitor	99.81%	Unkown
HY-153625	STM2120	Inhibitor	99.19%	Unkown
HY-159604	METTL3-IN-9	Inhibitor	95.30%	Unkown
HY-P10387A	RSM3 TFA	Inhibitor	98.83%	Unkown
HY-134673B	UZH1b	Inhibitor	99.85%	Unkown
HY-168878	EP652	Inhibitor	/	Unkown
HY-162930	PROTAC METTL3 degrader 1	Degrader	/	Unkown
HY-158403	METTL3-IN-7	Inhibitor	/	Unkown
HY-174873	AF151	Degrader	98.87%	Unkown
HY-178947	ZINC13000658	Inhibitor	99.78%	Unkown
HY-183186	EP102	Inhibitor	/	Unkown
HY-148467	METTL3-IN-1	Inhibitor	98.07%	Unkown
HY-148468	METTL3-IN-2	Inhibitor	/	Unkown
HY-179239	METTL3-IN-12	Inhibitor	/	Unkown
HY-154997	7OQL	Inhibitor	/	Unkown
HY-162282	PROTAC METTL3-14 degrader 1	Degrader	/	Unkown
HY-178446	METTL3-IN-11	Inhibitor	/	Unkown
HY-174874	POI-4		/	Unkown
HY-156759	METTL3-IN-5	Inhibitor	/	Unkown
HY-148469	METTL3-IN-3	Inhibitor	/	Unkown
HY-W125425	CHMA1004	Activator	/	Unkown
HY-181567	METTL3-IN-13	Inhibitor	/	Unkown
HY-N4031	Humantenine	Chemical	98%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	METTL3	VGNC	VGNC:63465
Mus musculus	METTL3	MGD	MGI:1927165
Rattus norvegicus	METTL3	RGD	RGD:1311750
Canis familiaris	METTL3	VGNC	VGNC:43177
Bos taurus	METTL3	VGNC	VGNC:31412
Others	METTL3	NCBI