2. Epigenetics
  3. METTL3
  4. METTL3-IN-13

METTL3-IN-13 is a METTL3 inhibitor. METTL3-IN-13 is applicable to the research of multiple cancers such as hypopharyngeal squamous cell carcinoma and non-small cell lung cancer.

For research use only. We do not sell to patients.

METTL3-IN-13

METTL3-IN-13 Chemical Structure

CAS No. : 3079150-70-9

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METTL3-IN-13 Related Antibodies

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Description

METTL3-IN-13 is a METTL3 inhibitor. METTL3-IN-13 is applicable to the research of multiple cancers such as hypopharyngeal squamous cell carcinoma and non-small cell lung cancer[1].

In Vitro

METTL3-IN-13 (Compound 142) (72 h) potently inhibits the viability of Calu-6, A549, Fadu, HCT-116, MDA-MB-231, PANC-1, 5637, DU 145 and PC-3, with an IC50 ≤ 200 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

METTL3-IN-13 Related Antibodies
In Vivo

METTL3-IN-13 (Compound 142) (30 mg/kg, i.p., once daily for 20 consecutive days) significantly inhibits subcutaneous hypopharyngeal squamous cell carcinoma tumor growth and prolongs survival in female NSG mice[1].
METTL3-IN-13 (30 mg/kg, i.p., once daily for 50 consecutive days) significantly prolongs the survival of female C.B-17 SCID mice in an orthotopic non-small cell lung adenocarcinoma model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) (female, 6-7 weeks old, subcutaneous FaDu human hypopharyngeal squamous cell carcinoma implantation)[1]
Dosage: 30 mg/kg
Administration: i.p.; daily; day 5 to day 24
Result: Reduced day 24 tumor volume to ~800 mm3 (vs ~2000 mm3 in vehicle control).
Prolonged survival: 80% survived to day 32, and 20% survived to day 40 (all vehicle-treated mice died by day 24).
Animal Model: C.B-17 SCID (C.B-17/IcrHsd-Prkdcscid) (female, 6-7 weeks old, orthotopic A549-Luc-C8 human non-small cell lung adenocarcinoma implantation)[1]
Dosage: 30 mg/kg
Administration: i.p.; daily; day 16 to day 66
Result: Prolonged survival: 50% survived to day 60, and 10% survived to day 75 (all vehicle-treated mice died by day 45).
Molecular Weight

462.59

Formula

C25H34N8O
CAS No.
SMILES

CC(N1C=CC(N2CCC[C@H](C2)NCC3CC3)=CC1=O)N4C=C(N=N4)C5=CC(N(C)C)=CN=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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METTL3-IN-13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

METTL3-IN-133079150-70-9METTL3Methyltransferase-like 3Calu-6 lung adenocarcinoma cellsA549 lung adenocarcinoma cellscarcinomaMDA-MB-231 breast adenocarcinoma cellsHepG2 hepatocellular carcinoma cells5637 urinary bladder carcinoma cellsPANC-1 pancreatic carcinoma cellsFaDu hypopharyngeal squamous cell carcinoma cellsHCT-116 colorectal carcinoma cellsInhibitorinhibitorinhibit

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