METTL3-IN-13
METTL3-IN-13 is a METTL3 inhibitor. METTL3-IN-13 is applicable to the research of multiple cancers such as hypopharyngeal squamous cell carcinoma and non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 3079150-70-9
- Formula: C25H34N8O
- Molecular Weight:462.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
METTL3-IN-13 (Compound 142) (72 h) potently inhibits the viability of Calu-6, A549, Fadu, HCT-116, MDA-MB-231, PANC-1, 5637, DU 145 and PC-3, with an IC50 ≤ 200 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
METTL3-IN-13 (30 mg/kg, i.p., once daily for 50 consecutive days) significantly prolongs the survival of female C.B-17 SCID mice in an orthotopic non-small cell lung adenocarcinoma model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) (female, 6-7 weeks old, subcutaneous FaDu human hypopharyngeal squamous cell carcinoma implantation)[1]
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Dosage:30 mg/kg
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Administration:i.p.; daily; day 5 to day 24
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Result:Reduced day 24 tumor volume to ~800 mm3 (vs ~2000 mm3 in vehicle control).
Prolonged survival: 80% survived to day 32, and 20% survived to day 40 (all vehicle-treated mice died by day 24).
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Animal Model:C.B-17 SCID (C.B-17/IcrHsd-Prkdcscid) (female, 6-7 weeks old, orthotopic A549-Luc-C8 human non-small cell lung adenocarcinoma implantation)[1]
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Dosage:30 mg/kg
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Administration:i.p.; daily; day 16 to day 66
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Result:Prolonged survival: 50% survived to day 60, and 10% survived to day 75 (all vehicle-treated mice died by day 45).
Chemical Information
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CAS No. 3079150-70-9
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Molecular Weight 462.59
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Formula C25H34N8O
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SMILES
CC(N1C=CC(N2CCC[C@H](C2)NCC3CC3)=CC1=O)N4C=C(N=N4)C5=CC(N(C)C)=CN=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
METTL3-IN-13 Related Classifications
HY-181567 Related Classifications
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- METTL3-IN-13
- 3079150-70-9
- METTL3
- Calu-6 lung adenocarcinoma cells
- A549 lung adenocarcinoma cells
- carcinoma
- MDA-MB-231 breast adenocarcinoma cells
- HepG2 hepatocellular carcinoma cells
- 5637 urinary bladder carcinoma cells
- PANC-1 pancreatic carcinoma cells
- FaDu hypopharyngeal squamous cell carcinoma cells
- HCT-116 colorectal carcinoma cells
- Inhibitor
- inhibitor
- inhibit