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Cat. No.: HY-174874

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POI-4

POI-4 is a ligand for METTL3. POI-4 can be used for synthesizing PROTACs such as AF151 (HY-174873).

For research use only. We do not sell to patients.

Formula: C₃₀H₃₄N₄O₂
Molecular Weight:482.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

POI-4 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

POI-4 is a ligand for METTL3. POI-4 can be used for synthesizing PROTACs such as AF151 (HY-174873)^[1].

Chemical Information

Molecular Weight 482.62
Formula C₃₀H₃₄N₄O₂
SMILES

O=C(NCC1=CC(NC(CN2CCC(C)(C)CC2)=C3)=C3C=C1)C4=CC(OCC5=CC=CC=C5)=CN=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Weldert AC, et al. Structure-guided design of a methyltransferase-like 3 (METTL3) proteolysis targeting chimera (PROTAC) incorporating an indole-nicotinamide chemotype. RSC Med Chem. 2025 Jun 19. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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