METTL3-IN-9
Based on 1 Customer Validation
METTL3-IN-9 (compound C3) is an inhibitor of methyltransferase-like METTL3, an RNA methyltransferase that catalyzes the N6-methyladenosine (m6A) modification of mRNA in eukaryotic cells.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 95.30%
- CAS No.: 295348-36-6
- 화학식: C34H20N2O8
- 분자량:584.53
-
보관:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
용액&용해도
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
IC50 & Target
METTL3[1]
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H1975 | IC50 |
180.2 μM
Compound: C3
|
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human NCI-H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
|
[PMID: 39291017] |
| PC-9 | IC50 |
216.4 μM
Compound: C3
|
Antiproliferative activity against human PC-9 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human PC-9 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
|
[PMID: 39291017] |
Chemical Information
-
CAS No. 295348-36-6
-
Appearance Solid
-
분자량 584.53
-
화학식 C34H20N2O8
-
Color White to off-white
-
SMILES
O=C1N(C2=CC=C(O)C=C2)C(C3=C1C=CC(OC4=CC=CC(OC5=CC6=C(C(N(C7=CC=C(O)C=C7)C6=O)=O)C=C5)=C4)=C3)=O
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : ≥ 100 mg/mL (171.08 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
-
Data Sheet (267 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7108 mL | 8.5539 mL | 17.1078 mL | 42.7694 mL |
| 5 mM | 0.3422 mL | 1.7108 mL | 3.4216 mL | 8.5539 mL | |
| 10 mM | 0.1711 mL | 0.8554 mL | 1.7108 mL | 4.2769 mL | |
| 15 mM | 0.1141 mL | 0.5703 mL | 1.1405 mL | 2.8513 mL | |
| 20 mM | 0.0855 mL | 0.4277 mL | 0.8554 mL | 2.1385 mL | |
| 25 mM | 0.0684 mL | 0.3422 mL | 0.6843 mL | 1.7108 mL | |
| 30 mM | 0.0570 mL | 0.2851 mL | 0.5703 mL | 1.4256 mL | |
| 40 mM | 0.0428 mL | 0.2138 mL | 0.4277 mL | 1.0692 mL | |
| 50 mM | 0.0342 mL | 0.1711 mL | 0.3422 mL | 0.8554 mL | |
| 60 mM | 0.0285 mL | 0.1426 mL | 0.2851 mL | 0.7128 mL | |
| 80 mM | 0.0214 mL | 0.1069 mL | 0.2138 mL | 0.5346 mL | |
| 100 mM | 0.0171 mL | 0.0855 mL | 0.1711 mL | 0.4277 mL |
METTL3-IN-9 Related Classifications
HY-159604 Related Classifications
Powered by Bioz