SGK1-IN-3
SGK1-IN-3 (Compound 3a) is an ATP-competitive SGK1 inhibitor with an IC50 of <1 nM against hSGK1. SGK1-IN-3 blocks the activity of CDK family members. SGK1-IN-3 is a P-glycoprotein substrate. SGK1-IN-3 can be used for research on osteoarthritis.
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- CAS No.: 2891696-18-5
- Formule: C23H20Cl2N6O3S
- Masse moléculaire:531.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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SGK1 <1 nM (IC50) |
SGK1-IN-3 potently inhibits recombinant hSGK1 protein, with an IC50 of <1 nM under both 10 μM ATP and 500 μM ATP conditions[1].
SGK1-IN-3 exhibits poor protein kinase selectivity and inhibits multiple off-target kinases at concentrations of <1 μM[1].
SGK1-IN-3 exhibits poor passive permeability across Caco2/TC7 cell monolayers, with a Ptot of <0.1 × 10-7 cm/s[1].
SGK1-IN-3 is metabolically unstable in rodent microsomal preparations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2891696-18-5
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Masse moléculaire 531.41
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Formule C23H20Cl2N6O3S
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SMILES
O=C(C1=CC(C2=CC=C(C=C2)NS(=O)(C3=C(C(Cl)=CC=C3)Cl)=O)=NC4=C1C=NN4)N[C@@H]5CCNC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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