α-Lipoic Acid sodium
Based on 14 publication(s) in Google Scholar
α-Lipoic Acid (Thioctic acid) sodium is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid sodium inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid sodium induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells. α-Lipoic Acid sodium can be used with CPUL1 (HY-151802) to construct the self-assembled nanoaggregate CPUL1-LA NA, which has improved antitumor efficacy than CPUL1.
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- Pureté: 99.95%
- CAS No.: 2319-84-8
- Formule: C8H13NaO2S2
- Masse moléculaire:228.31
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Stockage:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) α-Lipoic Acid sodium
More- J Nanostructure Chem. 13 May 2022.
- Cell Biosci. 2025 Oct 31;15(1):150. [Abstract]
- Inflammopharmacology. 2025 Sep;33(9):5563-5581. [Abstract]
- Eur J Pharmacol. 2025 May 5:994:177380. [Abstract]
- Int Immunopharmacol. 2025 May 16:155:114539. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Sep 7;1872(1):168034. [Abstract]
- Virol Sin. 2021 Dec;36(6):1520-1531. [Abstract]
- J Biochem Mol Toxicol. 2024 Jan;38(1):e23542. [Abstract]
- Immun Inflamm Dis. 2026 Jan;14(1):e70313. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- Neurosci Lett. 2025 Oct 14:865:138338. [Abstract]
- Res Sq. 2025 Dec 4.
- Oxid Med Cell Longev. 2021 Jun 4:2021:6633419. [Abstract]
- Oncotarget. 2018 Jan 30;9(15):12137-12153. [Abstract]
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Activité biologique
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HIV-1 |
NF-κB |
Human Endogenous Metabolite |
Microbial Metabolite |
The long terminal repeat (LTR) of HIV-1 is the target of cellular transcription factors such as NF-κB, and serves as the promoter-enhancer for the viral genome when integrated in host DNA[1]. α-Lipoic Acid (Alpha-Lipoic acid, ALA), a naturally occurring dithiol compound, plays an essential role in mitochondrial bioenergetics. α-Lipoic Acid reduces lipid accumulation in the liver by regulating the transcriptional factors SREBP-1, FoxO1, and Nrf2, and their downstream lipogenic targets via the activation of the SIRT1/LKB1/AMPK pathway. Treatment of cells with α-Lipoic Acid (250, 500 and 1000 μM) significantly increases the NAD+/NADH ratio in HepG2 cells (P<0.05 or P<0.01). Treatment with α-Lipoic Acid (50, 125, 250 and 500 μM) increases SIRT1 activity in HepG2 cells. α-Lipoic Acid (50, 125, 250, 500 and 1000 μM) increases phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in HepG2 cells in a dose-dependent fashion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2319-84-8
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Appearance Solid
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Masse moléculaire 228.31
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Formule C8H13NaO2S2
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Color Off-white to light yellow
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SMILES
O=C(O[Na])CCCCC1SSCC1
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Synonyms
Thioctic acid sodium; (±)-α-Lipoic acid sodium; DL-α-Lipoic acid sodium
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (14)
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Journal Impact Factor
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Most Recent
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Cell Biosci
FAK-dependent activation of src family kinase member BLK contributed to endometrial fibrosis via endoplasmic reticulum stress. [Abstract]2025 Oct 31;15(1):150. PMID: 41174819
α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2025 Oct 31;15(1):150. [Abstract]
Response experiments were performed in TGF-β1-induced hEndoSCs using siBlk and ERS activator (α-Lipoic Acid (α-LA)), successively. Detection of the protein expression levels by Western blot. In TGF-β1-induced hEndoSCs, Collagen I and α-SMA expression were downregulated by BLK knockdown using siBLK, and such inhibitory effect was counteracted by the ERS agonist α-Lipoic Acid (α-LA, 100 μM; 24 h).
α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2025 Oct 31;15(1):150. [Abstract]
Immunofluorescence detected the effect of intervention ERS on the expression of Collagen I (red) and α-SMA (green), respectively. DAPI (blue) was used to stain nuclei. The results showed that the ERS agonist α-Lipoic Acid (α-LA, 100 μM; 24 h) further upregulated the expression of Collagen I and α-SMA induced by TGF-β1.
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Inflammopharmacology
Therapeutic potential of alpha-lipoic acid on mitochondrial dynamics, oxidative/nitrosative stress, and histopathological changes in rat ulcerative colitis model. [Abstract]2025 Sep;33(9):5563-5581. PMID: 40889013
α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Inflammopharmacology. 2025 Sep;33(9):5563-5581. [Abstract]
The macroscopic appearance and macroscopic scores of colon tissues were evaluated in all groups. Compared with the C group, the colon tissue damage characterized by ulceration, hyperemia and mucosal edema was significantly increased in the UC group, M group (50 mg/kg; oral gavage; once daily for 14 days; rats) and α-lipoic acid (ALA) group (100 mg/kg; oral gavage; once daily for 14 days; rats) (p < 0.01). The macroscopic score was lower in the M + ALA group than in other colitis-induced groups, although the difference was not statistically significant (*p* > 0.05).
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Eur J Pharmacol
Alpha-lipoic acid alleviated intermittent hypoxia-induced myocardial injury in mice by promoting autophagy through Nrf2 signaling pathway. [Abstract]2025 May 5:994:177380. PMID: 39954840 -
Int Immunopharmacol
2025 May 16:155:114539. PMID: 40233449
α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 May 16:155:114539. [Abstract]
SH-SY5Y cell viability reached 80% with α-Lipoic Acid (α-ALA) pretreatment at 150 μmol/L for 8 h.
α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 May 16:155:114539. [Abstract]
TH and α-Synuclein Expression Analysis: The expression of TH in the brains of the 6-OHDA group decreased, while both α-Lipoic Acid (α-ALA, 40 mg/kg; i.p.; once daily for 14 days) pretreatment and treatment significantly improved TH expression. In contrast, the expression of α-synuclein in the brains of the 6-OHDA group increased. α-ALA treatment alleviated this change, but α-ALA pretreatment did not show improvement.
α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 May 16:155:114539. [Abstract]
In the open field test, 6-OHDA reduced the movement distance, and both α-Lipoic Acid (α-ALA, 40 mg/kg; i.p.; once daily for 14 days; C57BL/6 mice) pretreatment and α-ALA treatment ameliorated this effect (n = 9–10).
α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 May 16:155:114539. [Abstract]
TH expression decreased in the 6-OHDA group, but increased in both the α-Lipoic Acid (α-ALA, 40 mg/kg; i.p.; once daily for 14 days; C57BL/6 mice) + 6-OHDA and 6-OHDA+α-ALA groups.
α-Lipoic Acid sodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 May 16:155:114539. [Abstract]
α-Lipoic Acid (α-ALA, 40 mg/kg; i.p.; once daily for 14 days) pretreatment and treatment alleviated the upregulation of S100A9 protein expression induced by 6-OHDA in C57BL/6 mice, as validated by immunofluorescence analysis.
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Biochim Biophys Acta Mol Basis Dis
Alpha-lipoic acid attenuates cardiac inflammation of CVB3 induced viral myocarditis via neutrophil-derived YM-1. [Abstract]2025 Sep 7;1872(1):168034. PMID: 40925469 -
Virol Sin
α-Lipoic Acid Exerts Its Antiviral Effect against Viral Hemorrhagic Septicemia Virus (VHSV) by Promoting Upregulation of Antiviral Genes and Suppressing VHSV-Induced Oxidative Stress. [Abstract]2021 Dec;36(6):1520-1531. PMID: 34510367 -
J Biochem Mol Toxicol
Isoquercitrin promotes ferroptosis and oxidative stress in nasopharyngeal carcinoma via the AMPK/NF-κB pathway. [Abstract]2024 Jan;38(1):e23542. PMID: 37712196 -
Immun Inflamm Dis
Lipoic Acid Ameliorates Lipopolysaccharide-Induced Inflammation via Inhibition of Glycolysis in RAW264.7 Macrophages. [Abstract]2026 Jan;14(1):e70313. PMID: 41503676 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
Neurosci Lett
The mechanism of alpha-lipoic acid regulating dopaminergic neuronal damage in Parkinson's disease through the Nrf2/HMOX1 pathway. [Abstract]2025 Oct 14:865:138338. PMID: 40763886 -
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Oxid Med Cell Longev
α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells. [Abstract]2021 Jun 4:2021:6633419. PMID: 34211631 -
Oncotarget
Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. [Abstract]2018 Jan 30;9(15):12137-12153. PMID: 29552298
Solvant et solubilité
H2O : 35 mg/mL (153.30 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
The human hepatocellular carcinoma (HepG2) cell line is cultured in Dulbecco's modified Eagle's medium containing 10% fetal bovine serum at 37°C and 5% CO2. HepG2 cells are treated with AMPK inhibitor (CC, 20 μM, 0.5 h), SIRT1 inhibitor (NA, 10 mM, 12 or 24 h), and AMPK activator (AICAR, 2 mM, 1 h), Palmitate (PA, 125 μM, 12 h) and α-Lipoic Acid (250 μM, 6 or 12 h)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pureté et documentation
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Fiche technique (275 KB)
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SDS (761 KB)
- English - EN (761 KB)
- Français - FR (761 KB)
- Deutsch - DE (761 KB)
- Norwegian - NO (761 KB)
- Español - ES (761 KB)
- Swedish - SV (761 KB)
- Italian - IT (761 KB)
- Korean - KR (761 KB)
- Portuguese - PT (761 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65. [Content Brief]
[2]. Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153. [Content Brief]
[3]. Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25(11):1207-1217. [Content Brief]
[4]. Pibiri M, et al. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020 Apr 28;10(1):7139. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 4.3800 mL | 21.9000 mL | 43.8001 mL | 109.5002 mL |
| 5 mM | 0.8760 mL | 4.3800 mL | 8.7600 mL | 21.9000 mL | |
| 10 mM | 0.4380 mL | 2.1900 mL | 4.3800 mL | 10.9500 mL | |
| 15 mM | 0.2920 mL | 1.4600 mL | 2.9200 mL | 7.3000 mL | |
| 20 mM | 0.2190 mL | 1.0950 mL | 2.1900 mL | 5.4750 mL | |
| 25 mM | 0.1752 mL | 0.8760 mL | 1.7520 mL | 4.3800 mL | |
| 30 mM | 0.1460 mL | 0.7300 mL | 1.4600 mL | 3.6500 mL | |
| 40 mM | 0.1095 mL | 0.5475 mL | 1.0950 mL | 2.7375 mL | |
| 50 mM | 0.0876 mL | 0.4380 mL | 0.8760 mL | 2.1900 mL | |
| 60 mM | 0.0730 mL | 0.3650 mL | 0.7300 mL | 1.8250 mL | |
| 80 mM | 0.0548 mL | 0.2738 mL | 0.5475 mL | 1.3688 mL | |
| 100 mM | 0.0438 mL | 0.2190 mL | 0.4380 mL | 1.0950 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
α-Lipoic Acid sodium Related Classifications
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