1. Others NF-κB Anti-infection Metabolic Enzyme/Protease Apoptosis
  2. Isotope-Labeled Compounds NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
  3. α-Lipoic Acid-d5

α-Lipoic Acid-d5  (Synonyms: Thioctic acid-d5; (±)-α-Lipoic acid-d5; DL-α-Lipoic acid-d5)

Cat. No.: HY-N0492S Purity: ≥96.0%
COA Handling Instructions

α-Lipoic Acid-d5 is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

For research use only. We do not sell to patients.

α-Lipoic Acid-d<sub>5</sub> Chemical Structure

α-Lipoic Acid-d5 Chemical Structure

CAS No. : 1189471-66-6

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Based on 1 publication(s) in Google Scholar

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Description

α-Lipoic Acid-d5 is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

IC50 & Target

HIV-1

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

211.36

Formula

C8H9D5O2S2

CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC(CCCC([2H])([2H])C1([2H])C([2H])([2H])CSS1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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α-Lipoic Acid-d5
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