α-Lipoic Acid-d5
Based on 1 publication(s) in Google Scholar
α-Lipoic Acid-d5 is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.11%
- CAS No.: 1189471-66-6
- Formule: C8H9D5O2S2
- Masse moléculaire:211.36
-
Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) α-Lipoic Acid-d5
MoreVoir tous les produits spécifiques à Isoform Endogenous Metabolite
More
Activité biologique
Description
IC50 & Target
|
HIV-1 |
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
CAS No. 1189471-66-6
-
Unlabeled CAS 1077-28-7
-
Appearance Solid
-
Masse moléculaire 211.36
-
Formule C8H9D5O2S2
-
Color Off-white to light yellow
-
SMILES
OC(CCCC([2H])([2H])C1([2H])C([2H])([2H])CSS1)=O
-
Synonyms
Thioctic acid-d5; (±)-α-Lipoic acid-d5; DL-α-Lipoic acid-d5
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
bioRxiv
Functional partitioning of lipoic acid decouples cellular abundance from mitochondrial utilization. [Abstract]2026 May 23:2026.05.22.727209. PMID: 42239357
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (473.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 0.1 mg/mL (0.47 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65.;Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25(11):1207-1217.;Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153.;Pibiri M, et al. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020 Apr 28;10(1):7139. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7313 mL | 23.6563 mL | 47.3126 mL | 118.2816 mL |
| 5 mM | 0.9463 mL | 4.7313 mL | 9.4625 mL | 23.6563 mL | |
| 10 mM | 0.4731 mL | 2.3656 mL | 4.7313 mL | 11.8282 mL | |
| 15 mM | 0.3154 mL | 1.5771 mL | 3.1542 mL | 7.8854 mL | |
| 20 mM | 0.2366 mL | 1.1828 mL | 2.3656 mL | 5.9141 mL | |
| 25 mM | 0.1893 mL | 0.9463 mL | 1.8925 mL | 4.7313 mL | |
| 30 mM | 0.1577 mL | 0.7885 mL | 1.5771 mL | 3.9427 mL | |
| 40 mM | 0.1183 mL | 0.5914 mL | 1.1828 mL | 2.9570 mL | |
| 50 mM | 0.0946 mL | 0.4731 mL | 0.9463 mL | 2.3656 mL | |
| 60 mM | 0.0789 mL | 0.3943 mL | 0.7885 mL | 1.9714 mL | |
| 80 mM | 0.0591 mL | 0.2957 mL | 0.5914 mL | 1.4785 mL | |
| 100 mM | 0.0473 mL | 0.2366 mL | 0.4731 mL | 1.1828 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
α-Lipoic Acid-d5 Related Classifications
HY-N0492S Related Classifications
Powered by Bioz