CHNQD-01748
CHNQD-01748 is an Antibacterial agent. CHNQD-01748 disrupts mature biofilms and bacterial membranes, leading to bacterial lysis. CHNQD-01748 exhibits selective antibacterial activity against S. aureus and MRSA, with negligible activity against other Gram-positive bacteria, Gram-negative bacteria, and fungi. CHNQD-01748 can be used for research on MRSA infections.
For research use only. We do not sell to patients.
- CAS No.: 3096111-98-4
- Formula: C15H7I3N2O3
- Molecular Weight:643.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
CHNQD-01748 (256-0.5 μg/mL; 24 h) demonstrates potent antibacterial activity against the reference MRSA strain ATCC 43300 with an MIC of 4 μg/mL[1].
CHNQD-01748 (100 μM; 72 h) shows a favorable preliminary safety profile with minimal cytotoxicity against L-02, HUVEC, and BV2 cell lines, maintaining over 95% cell viability at 100 μM[1].
CHNQD-01748 (2 × MIC; 48 h) possesses prolonged antibacterial efficacy against the reference MRSA strain ATCC 43300, achieving complete bactericidal activity at 2 × MIC over 48 h[1].
CHNQD-01748 (1 × MIC) induces severe morphological damage and membrane collapse in the reference MRSA strain ATCC 43300 at 1 × MIC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:L-02, HUVEC, BV2
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Concentration:100 μM
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Incubation Time:72 h
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Result:Displayed minimal cytotoxicity across all three mammalian cell lines (L-02, HUVEC, and BV2), with cell viability remaining above 95% at 100 μM.
Parmacokinetics
| Species | Dose | Route | T1/2 | Cmax | C0 | AUC0-t | MRT |
|---|---|---|---|---|---|---|---|
| Mice[1] | 2 mg/kg | i.v. | 20.5 h | 3.06×104 ng/mL | 3.43×104 ng/mL | 1.27×105 ng/mL·h | 28.1 h |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR (female, six weeks old)[1]
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Dosage:5 mg/kg
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Administration:s.c.; at 2 h, 6 h, and 10 h post-infection; three doses
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Result:Reduced the bacterial burden in infected skin.
Outperformed vancomycin in limiting bacterial dissemination from the infection focus to distant organs, achieving inhibition rates of 96.1% in the spleen, 95.9% in the lung, and 99.4% in the kidney.
Chemical Information
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CAS No. 3096111-98-4
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Molecular Weight 643.94
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Formula C15H7I3N2O3
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SMILES
O=C1NC(C(C2=CC(I)=C(O)C(I)=C2)=O)=NC3=C1C=CC=C3I
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CHNQD-01748 Related Classifications
HY-189347 Related Classifications
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