ChoKα inhibitor-5
ChoKα inhibitor-5 is a sulphur-containing choline kinase inhibitor. ChoKα inhibitor-5 can inhibit HChoK α1 with an IC50 value of 0.64 μM. ChoKα inhibitor-5 also can induce apoptosis. ChoKα inhibitor-5 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 2883822-66-8
- Formula: C42H48Br2N4S4
- Molecular Weight:896.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.66 μM (HChoK α1);1.29 μM (A549); 4.63 μM (HeLa); 2.41 μM (HT-29); 1.92 μM (MDA-MB-231); 2.12 μM (MCF7) [1]
ChoKα inhibitor-5 (PL 69) has HChoK α1 inhibition activity with an IC50 value of 0.64 μM[1].
ChoKα inhibitor-5 (1.46 μM; 72 h) can inhibit cell proliferation for A549, HeLa, HT-29, MDA-MB-231 and MCF7 cells with IC50 values of 1.29 μM, 4.63 μM, 2.41 μM, 1.92 μM and 2.12 μM, respectively[1].
ChoKα inhibitor-5 (1, 5 μM; 48, 72 h) induces apoptosis in cancer cells through the mitochondrial pathway[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT29, A549, HeLa, HT-29, MDA-MB-231 and MCF7 cells
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Concentration:2.47 μM
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Incubation Time:72 h
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Result:Had anti-proliferative property.
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Cell Line:A549 and HeLa cells
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Concentration:1, 5 μM
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Incubation Time:48, 72 h
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Result:Induced a stronger mitochondrial depolarization in HeLa cells at early time-point treatment (24 h).
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Cell Line:HeLa and NHA cells
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Concentration:5 μM
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Incubation Time:48 h
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Result:Significantly reduced the expression of the anti-apoptotic protein MCL-1.
Chemical Information
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CAS No. 2883822-66-8
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Molecular Weight 896.93
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Formula C42H48Br2N4S4
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SMILES
C12=[N+](CC3=CC=C(C=C3)SCCSC4=CC=C(C[N+]5=C6C=CSC6=C(N7CCCCCC7)C=C5)C=C4)C=CC(N8CCCCCC8)=C1SC=C2.[Br-].[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ChoKα inhibitor-5 Related Classifications
HY-152195 Related Classifications
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