2. Metabolic Enzyme/Protease
  3. SULT
  4. Chst15-IN-1

Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair.

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Chst15-IN-1

Chst15-IN-1 構造式

CAS 番号 : 2158198-77-5

容量 価格（税別） 在庫状況 数量
>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 104 在庫あり
Solution
10 mM * 1 mL in DMSO USD 104 在庫あり
Solid
5 mg $95 在庫あり
10 mg $150 在庫あり
25 mg $285 在庫あり
50 mg $450 在庫あり
100 mg $730 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

Chst15-IN-1 関連抗体

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製品説明

Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair[1].

IC50 & Target

Chst15[1]
体外実験

Chst15-IN-1 (25 μM; 24 hours; Neu7 astrocytes) is selective for sulfotransferases over the myriad of reactive cysteine-containing proteins. Chst15-IN-1 (10 and 25 μM; Neu7 astrocytes) shows a significant dose dependent decrease in cell-surface CS-E expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chst15-IN-1 関連抗体
体内実験

Chst15-IN-1 (3.0 mg/kg; i.v.) has a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 hours[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats
Dosage: 3.0 mg/kg (Pharmacokinetic Analysis)
Administration: I.v.
Result: Had a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 h.
分子量

442.09

分子式

C17H11BrCl2N2O3
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC=C(Cl)C=C1Cl)/C(C#N)=C/C2=CC(OC)=C(O)C(Br)=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (113.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2620 mL 11.3099 mL 22.6198 mL
5 mM 0.4524 mL 2.2620 mL 4.5240 mL
10 mM 0.2262 mL 1.1310 mL 2.2620 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2620 mL 11.3099 mL 22.6198 mL 56.5496 mL
5 mM 0.4524 mL 2.2620 mL 4.5240 mL 11.3099 mL
10 mM 0.2262 mL 1.1310 mL 2.2620 mL 5.6550 mL
15 mM 0.1508 mL 0.7540 mL 1.5080 mL 3.7700 mL
20 mM 0.1131 mL 0.5655 mL 1.1310 mL 2.8275 mL
25 mM 0.0905 mL 0.4524 mL 0.9048 mL 2.2620 mL
30 mM 0.0754 mL 0.3770 mL 0.7540 mL 1.8850 mL
40 mM 0.0565 mL 0.2827 mL 0.5655 mL 1.4137 mL
50 mM 0.0452 mL 0.2262 mL 0.4524 mL 1.1310 mL
60 mM 0.0377 mL 0.1885 mL 0.3770 mL 0.9425 mL
80 mM 0.0283 mL 0.1414 mL 0.2827 mL 0.7069 mL
100 mM 0.0226 mL 0.1131 mL 0.2262 mL 0.5655 mL
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Chst15-IN-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chst15-IN-12158198-77-5SULTSulfotransferasepotentreversiblecovalenteffectivelychondroitinsulfate-EGAGneuronalInhibitorinhibitorinhibit

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製品名:
Chst15-IN-1
製品番号:
HY-124704
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