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Cat. No.: HY-W002798

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Cyclopropanesulfonyl chloride

Name: Cyclopropanesulfonyl chloride
Brand: MedChemExpress
SKU: HY-W002798
Price: 25.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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Cyclopropanesulfonyl chloride is a sulfonyl chloride reagent and synthetic building block, which serves as an intermediate for organic synthesis-related research.

For research use only. We do not sell to patients.

Purity: 99.89%
CAS No.: 139631-62-2
Formula: C₃H₅ClO₂S
Molecular Weight:140.59

Storage:

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Cyclopropanesulfonyl chloride Chemical Structure

CAS No.: 139631-62-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

HY-Y0351
Phenylthiourea

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Cyclopropanesulfonyl chloride is a sulfonyl chloride reagent and synthetic building block, which serves as an intermediate for organic synthesis-related research^[1]^[2].

In Vitro

Cyclopropanesulfonyl chloride (8-12 h; room temperature) reacts with evodiamine in the presence of Na⁺H⁻ at room temperature to form N13-cyclopropanesulfonyl evodiamine (3g) with 49% yield^[1].
Cyclopropanesulfonyl chloride reacts with benzene-1,2-diamine to form intermediate 2, a precursor for the synthesis of cyclopropanesulfonamide-based EGFR inhibitors targeting EGFR^C797S mutations^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 139631-62-2
Appearance Liquid (Density: 1.38 g/cm³)
Molecular Weight 140.59
Formula C₃H₅ClO₂S
Color Colorless to light yellow
SMILES

O=S(C1CC1)(Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (477 KB)
- English - EN (477 KB)
- Français - FR (477 KB)
- Deutsch - DE (477 KB)
- Norwegian - NO (477 KB)
- Español - ES (477 KB)
- Swedish - SV (477 KB)
- Italian - IT (477 KB)
- Korean - KR (477 KB)
- Portuguese - PT (477 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liang C Y, et al. Synthesis, in vitro and in vivo antitumor activity and docking studies of new evodiamine derivatives. Journal of Chemical and Pharmaceutical Research, 2014, 6(3): 1161‑1171.

[2]. Wang M, et al. Design, Synthesis and Evaluation of Novel Cyclopropanesulfonamide Derivatives for the Treatment of EGFR Mutation in Non-Small Cell Lung Cancer. Drug design, development and therapy. 2025;19:1403-1420.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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