NOTCH1 Protein, Human (HEK293, His-Avi)

NOTCH1 protein serves as a receptor for membrane-bound ligands, including Jagged-1 (JAG1), Jagged-2 (JAG2), and Delta-1 (DLL1), exerting critical regulatory functions in cell-fate determination. Upon ligand activation, the released Notch intracellular domain (NICD) forms a transcriptional activator complex with RBPJ/RBPSUH, orchestrating the activation of genes within the enhancer of split locus. NOTCH1 significantly influences cellular differentiation, proliferation, and apoptotic programs. Beyond its role in angiogenesis, where it negatively regulates endothelial cell proliferation and migration, NOTCH1 is involved in thymic maturation, follicular differentiation, and cell fate selection within the follicle. Additionally, it plays a crucial role in cerebellar development by acting as a receptor for neuronal DNER, contributing to the differentiation of Bergmann glia. NOTCH1 also plays roles in postimplantation development, mesoderm development, somite formation, and neurogenesis. It interacts with various proteins, including DNER, DTX1, DTX2, RBPJ/RBPSUH, MAML1, MAML2, MAML3, SNW1, AAK1, FBXW7, SGK1, HIF1AN, SNAI1, MDM2A, BCL6, THBS4, CCN3, DLL4, ZMIZ1, MEGF10, PRAG1, PSEN1, and ZFP64, forming a complex network that modulates diverse cellular processes and regulatory pathways.