DBCO-NHCO-PEG6-Biotin
Based on 1 Customer Validation
DBCO-NHCO-PEG6-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG6-Biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 96.65%
- CAS No.: 3081794-36-4
- Formula: C43H59N5O10S
- Molecular Weight:838.02
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Storage:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3081794-36-4
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Appearance Oil
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Molecular Weight 838.02
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Formula C43H59N5O10S
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Color Colorless to light yellow
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SMILES
O=C(N1)N[C@](CS2)([H])[C@@]1([H])[C@@H]2CCCCC(NCCOCCOCCOCCOCCOCCOCCC(NCCC(N3C4=CC=CC=C4C#CC5=CC=CC=C5C3)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 50 mg/mL (59.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1933 mL | 5.9664 mL | 11.9329 mL | 29.8322 mL |
| 5 mM | 0.2387 mL | 1.1933 mL | 2.3866 mL | 5.9664 mL | |
| 10 mM | 0.1193 mL | 0.5966 mL | 1.1933 mL | 2.9832 mL | |
| 15 mM | 0.0796 mL | 0.3978 mL | 0.7955 mL | 1.9888 mL | |
| 20 mM | 0.0597 mL | 0.2983 mL | 0.5966 mL | 1.4916 mL | |
| 25 mM | 0.0477 mL | 0.2387 mL | 0.4773 mL | 1.1933 mL | |
| 30 mM | 0.0398 mL | 0.1989 mL | 0.3978 mL | 0.9944 mL | |
| 40 mM | 0.0298 mL | 0.1492 mL | 0.2983 mL | 0.7458 mL | |
| 50 mM | 0.0239 mL | 0.1193 mL | 0.2387 mL | 0.5966 mL |
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