2. Epigenetics
  3. WDR5
  4. DDO-2213

DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC50 of 29 nM and a Kd value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research.

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DDO-2213

DDO-2213 構造式

CAS 番号 : 2378768-36-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 160 在庫あり
Solution
10 mM * 1 mL in DMSO USD 160 在庫あり
Solid
5 mg $150 在庫あり
10 mg $250 在庫あり
25 mg $500 在庫あり
50 mg $800 在庫あり
100 mg $1280 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

DDO-2213 関連抗体

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  • 純度とドキュメンテーション

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製品説明

DDO-2213 is an orally active and potent WDR5-MLL1 inhibitor, with an IC50 of 29 nM and a Kd value of 72.9 nM for the WDR5 protein. DDO-2213 selectively inhibits MLL (mixed lineage leukemia) histone methyltransferase activity and the proliferation of MLL translocation-harboring cells. DDO-2213 can be used for MLL fusion leukemia research[1].

Cellular Effect
Cell Line Type Value Description References
HUVEC IC50
> 100 μM
Compound: 63; DDO-2213
Antiproliferative activity against human HUVEC cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human HUVEC cells assessed as cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34105966]
K562 IC50
> 100 μM
Compound: 63; DDO-2213
Antiproliferative activity against human K562 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human K562 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34105966]
MOLM-13 GI50
13.09 μM
Compound: DDO-2213
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay
[PMID: 34283608]
MOLM-13 IC50
13.1 μM
Compound: 63; DDO-2213
Antiproliferative activity against human MOLM-13 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MOLM-13 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34105966]
MV4-11 GI50
12.57 μM
Compound: DDO-2213
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell proliferation measured after 5 days by ATPlite assay
[PMID: 34283608]
MV4-11 IC50
12.6 μM
Compound: 63; DDO-2213
Antiproliferative activity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
Antiproliferative activity against human MV4-11 cells assessed as cell viability incubated for 72 hrs by CCK8 assay
[PMID: 34105966]
分子量

483.97

分子式

C24H27ClFN7O
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C2=CC(NC3=NC=NC(Cl)=C3N)=C(N4CCN(C)CC4)C=C2F)C=C1)N(C)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (206.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0662 mL 10.3312 mL 20.6624 mL
5 mM 0.4132 mL 2.0662 mL 4.1325 mL
10 mM 0.2066 mL 1.0331 mL 2.0662 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

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体積 （開始）

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In Vivo Dissolution Calculator
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純度とドキュメンテーション

純度: 98.84%

COA (251 KB) HNMR (295 KB) LCMS (104 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0662 mL 10.3312 mL 20.6624 mL 51.6561 mL
5 mM 0.4132 mL 2.0662 mL 4.1325 mL 10.3312 mL
10 mM 0.2066 mL 1.0331 mL 2.0662 mL 5.1656 mL
15 mM 0.1377 mL 0.6887 mL 1.3775 mL 3.4437 mL
20 mM 0.1033 mL 0.5166 mL 1.0331 mL 2.5828 mL
25 mM 0.0826 mL 0.4132 mL 0.8265 mL 2.0662 mL
30 mM 0.0689 mL 0.3444 mL 0.6887 mL 1.7219 mL
40 mM 0.0517 mL 0.2583 mL 0.5166 mL 1.2914 mL
50 mM 0.0413 mL 0.2066 mL 0.4132 mL 1.0331 mL
60 mM 0.0344 mL 0.1722 mL 0.3444 mL 0.8609 mL
80 mM 0.0258 mL 0.1291 mL 0.2583 mL 0.6457 mL
100 mM 0.0207 mL 0.1033 mL 0.2066 mL 0.5166 mL
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DDO-2213 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDO-22132378768-36-4DDO2213DDO 2213WDR5WD repeat protein-5WD40 repeat domain protein 5MLL Fusion LeukemiaWD repeat-containing protein 5MV4-11 tumorInhibitorinhibitorinhibit

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製品名:
DDO-2213
製品番号:
HY-153331
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