2. PROTAC
  3. PROTAC Linkers
  4. DOTA-PEG5-C6-DBCO

DOTA-PEG5-C6-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DOTA-PEG5-C6-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DOTA-PEG5-C6-DBCO

DOTA-PEG5-C6-DBCO Estructura química

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5 mg En stock
10 mg En stock
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200 mg   Obtener un presupuesto  

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DOTA-PEG5-C6-DBCO Related Antibodies

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Actividad biológica

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  • Referencias

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Descripciòn

DOTA-PEG5-C6-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DOTA-PEG5-C6-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DOTA-PEG5-C6-DBCO Related Antibodies
Peso molecular

982.13

Fòrmula

C49H71N7O14
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCCCC(NCCOCCOCCOCCOCCOCCNC(CN4CCN(CCN(CCN(CC4)CC(O)=O)CC(O)=O)CC(O)=O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 125 mg/mL (127.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (101.82 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0182 mL 5.0910 mL 10.1820 mL
5 mM 0.2036 mL 1.0182 mL 2.0364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

Purity: 97.93%

SDS (251 KB)

COA (256 KB) HNMR (279 KB) RP-HPLC (229 KB) MS (69 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 1.0182 mL 5.0910 mL 10.1820 mL 25.4549 mL
5 mM 0.2036 mL 1.0182 mL 2.0364 mL 5.0910 mL
10 mM 0.1018 mL 0.5091 mL 1.0182 mL 2.5455 mL
15 mM 0.0679 mL 0.3394 mL 0.6788 mL 1.6970 mL
20 mM 0.0509 mL 0.2545 mL 0.5091 mL 1.2727 mL
25 mM 0.0407 mL 0.2036 mL 0.4073 mL 1.0182 mL
30 mM 0.0339 mL 0.1697 mL 0.3394 mL 0.8485 mL
40 mM 0.0255 mL 0.1273 mL 0.2545 mL 0.6364 mL
50 mM 0.0204 mL 0.1018 mL 0.2036 mL 0.5091 mL
60 mM 0.0170 mL 0.0848 mL 0.1697 mL 0.4242 mL
80 mM 0.0127 mL 0.0636 mL 0.1273 mL 0.3182 mL
100 mM 0.0102 mL 0.0509 mL 0.1018 mL 0.2545 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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DOTA-PEG5-C6-DBCO Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DOTA-PEG5-C6-DBCOPROTAC LinkersInhibitorinhibitorinhibit

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Nombre del producto:
DOTA-PEG5-C6-DBCO
Cat. No.:
HY-140314
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