DPPE-PEG2000-GNYTCEVTELTREGETIIELK

DPPE-PEG2000-GNYTCEVTELTREGETIIELK is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphoethanolamine): Lipid anchoring group-inserted into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. GNYTCEVTELTREGETIIELK peptide: Targeting/functional ligand - GNYTCEVTELTREGETIIELK peptide is a CD47 protein functional mimicry peptide that can mimic the interaction between CD47 and signal regulatory protein α (SIRPα), sending a 'don't eat me' signal to macrophages and inhibiting phagocytic activity.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.