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Cat. No.: HY-162300

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EGFR kinase inhibitor 4

EGFR kinase inhibitor 4 (Compound 4) is a bivalent ATP-allosteric EGFR inhibitor (IC₅₀: 1.8 nM for mutant EGFR (LRTMCS)). EGFR kinase inhibitor 4 can be used for research of NSCLC.

For research use only. We do not sell to patients.

CAS No.: 2922402-05-7
Formula: C₄₀H₃₄N₈O₄
Molecular Weight:690.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

EGFR kinase inhibitor 4 Chemical Structure

CAS No.: 2922402-05-7

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

EGFR kinase inhibitor 4 (Compound 4) is a bivalent ATP-allosteric EGFR inhibitor (IC₅₀: 1.8 nM for mutant EGFR (LRTMCS)). EGFR kinase inhibitor 4 can be used for research of NSCLC^[1].

IC₅₀ & Target

IC50: 1.8 nM for mutant EGFR (LRTMCS)^[1]

All EGFR Isoforms :

In Vitro

EGFR kinase inhibitor 4 (0-10 µM, 6 h) inhibits LRTM phosphorylation (pY1068) and downstream pERK and pAKT in the human NSCLC cell lines (H1975, H3255, HCC827 cells)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2922402-05-7
Molecular Weight 690.75
Formula C₄₀H₃₄N₈O₄
SMILES

O=C(NC1=CC=CC(C2=C(NC(CC)=N2)C3=CC=NC(NC4=C(OC)C=CC(NC(C=C)=O)=C4)=C3)=C1)C5=C6NC(C7=C(NC6=CC=C5)C=CC=C7)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wittlinger F, et al. Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors. Commun Chem. 2024 Feb 20;7(1):38. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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EGFR kinase inhibitor 4

All EGFR Isoforms