Fmoc-NH-PEG5-C2-NH2 hydrochloride

Cat. No.: HY-134682A Purity: 98.98%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Fmoc-NH-PEG5-C2-NH2 hydrochloride is a PEG-based PROTAC linker. Fmoc-NH-PEG5-C2-NH2 hydrochloride can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Fmoc-NH-PEG5-C2-NH2 hydrochloride Chemical Structure

Size	Stock	Quantity
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	Get quote
5 g	Get quote

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Other Forms of Fmoc-NH-PEG5-C2-NH2 hydrochloride:

Fmoc-NH-PEG5-C2-NH2 In-stock

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Biological Activity
Purity & Documentation
References
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Description

Fmoc-NH-PEG5-C2-NH2 hydrochloride is a PEG-based PROTAC linker. Fmoc-NH-PEG5-C2-NH2 hydrochloride can be used in the synthesis of PROTACs^[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

539.06

Formula

C₂₇H₃₉ClN₂O₇

Appearance

Oil

Color

Off-white to light yellow

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCN.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (185.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8551 mL	9.2754 mL	18.5508 mL
5 mM	0.3710 mL	1.8551 mL	3.7102 mL
10 mM	0.1855 mL	0.9275 mL	1.8551 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.98%

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Data Sheet (266 KB) SDS (252 KB)

COA (242 KB) HNMR (274 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8551 mL	9.2754 mL	18.5508 mL	46.3770 mL
	5 mM	0.3710 mL	1.8551 mL	3.7102 mL	9.2754 mL
	10 mM	0.1855 mL	0.9275 mL	1.8551 mL	4.6377 mL
	15 mM	0.1237 mL	0.6184 mL	1.2367 mL	3.0918 mL
	20 mM	0.0928 mL	0.4638 mL	0.9275 mL	2.3189 mL
	25 mM	0.0742 mL	0.3710 mL	0.7420 mL	1.8551 mL
	30 mM	0.0618 mL	0.3092 mL	0.6184 mL	1.5459 mL
	40 mM	0.0464 mL	0.2319 mL	0.4638 mL	1.1594 mL
	50 mM	0.0371 mL	0.1855 mL	0.3710 mL	0.9275 mL
	60 mM	0.0309 mL	0.1546 mL	0.3092 mL	0.7730 mL
	80 mM	0.0232 mL	0.1159 mL	0.2319 mL	0.5797 mL
	100 mM	0.0186 mL	0.0928 mL	0.1855 mL	0.4638 mL