FXR/TGR5 agonist 1

Cat. No.: HY-142159 Purity: 98.03%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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FXR/TGR5 agonist 1 has agonist action on FXR and TGR5, and can be used for the research of fatty liver disease.

For research use only. We do not sell to patients.

FXR/TGR5 agonist 1 Chemical Structure

CAS No. : 2677689-72-2

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Purity & Documentation
References
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Description

FXR/TGR5 agonist 1 has agonist action on FXR and TGR5, and can be used for the research of fatty liver disease.

Molecular Weight

530.06

Formula

C₃₁H₃₂ClN₃O₃

CAS No.

2677689-72-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(C)C=NC=C1)N(C2=CC(OC)=CC(Cl)=C2)CC3(CC4)CCC4(C5=CC=C(OC)C(C#N)=C5)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 20 mg/mL (37.73 mM; ultrasonic and adjust pH to 3 with 1 M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8866 mL	9.4329 mL	18.8658 mL
5 mM	0.3773 mL	1.8866 mL	3.7732 mL
10 mM	0.1887 mL	0.9433 mL	1.8866 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.03%

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Data Sheet (270 KB) SDS (251 KB)

COA (253 KB) HNMR (287 KB) LCMS (325 KB)

Handling Instructions (2659 KB)

References

[1]. Tokuyama R, et al. Novel amide derivative. JP2021109846A.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.8866 mL	9.4329 mL	18.8658 mL	47.1645 mL
	5 mM	0.3773 mL	1.8866 mL	3.7732 mL	9.4329 mL
	10 mM	0.1887 mL	0.9433 mL	1.8866 mL	4.7164 mL
	15 mM	0.1258 mL	0.6289 mL	1.2577 mL	3.1443 mL
	20 mM	0.0943 mL	0.4716 mL	0.9433 mL	2.3582 mL
	25 mM	0.0755 mL	0.3773 mL	0.7546 mL	1.8866 mL
	30 mM	0.0629 mL	0.3144 mL	0.6289 mL	1.5721 mL