S119-8
Based on 1 Customer Validation
S119-8 is a broad spectrum inhibitor of influenza A and B viruses, showing activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.73%
- No. CAS: 443639-96-1
- Fòrmula: C23H24N2O
- Peso molecular:344.45
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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HY-50001
Nucleozin -
HY-109025A
Baloxavir -
HY-13210
Zanamivir -
HY-109025
Baloxavir marboxil -
HY-17016
Oseltamivir phosphate -
HY-17015
Peramivir trihydrate -
HY-17015R
Peramivir trihydrate (Standard) -
HY-12353A
Pimodivir -
HY-B0338
Rimantadine -
HY-17015A
Peramivir -
HY-109025R
Baloxavir marboxil (Standard) -
HY-14904A
Umifenovir hydrochloride
Actividad biológica
Descripciòn
IC50 & Target
Influenza A and B[1]
In Vitro
S119-8 is an analog of S119. S119-8 has acquired enhanced broad-spectrum activity with improved calculated physical properties, while maintaining significant potency (IC50=1.43 μM) at non-toxic (CC50=66.10 μM) concentrations, albeit somewhat higher (7-fold) than that of the parent S119 against influenza A/WSN/33 H1N1 (WSN) virus. S119-8 also shows activity against multiple influenza B viruses and an oseltamivir-resistant influenza A virus, but does not inhibit a non-influenza virus, vesicular stomatitis nirus (VSV). S119-8 has increased breadth of inhibition against influenza A and B viruses accompanied by only a small loss in potency. S119-8 inhibits influenza viruses A/Puerto Rico/8/1934 (H1N1) (PR8) with an IC50 of 6.05 μM. S119-8 inhibits influenza A/Vietnam/1203/2004 (H5N1) with an IC50 of 8.42 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 443639-96-1
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Appearance Solid
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Peso molecular 344.45
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Fòrmula C23H24N2O
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Color Light yellow to yellow
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SMILES
O=C(NC1=CC=C(NC2=CC=CC=C2)C=C1)C3=CC=C(C(C)(C)C)C=C3
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvente y solubilidad
In Vitro:
DMSO : ≥ 150 mg/mL (435.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9032 mL | 14.5159 mL | 29.0318 mL | 72.5795 mL |
| 5 mM | 0.5806 mL | 2.9032 mL | 5.8064 mL | 14.5159 mL | |
| 10 mM | 0.2903 mL | 1.4516 mL | 2.9032 mL | 7.2579 mL | |
| 15 mM | 0.1935 mL | 0.9677 mL | 1.9355 mL | 4.8386 mL | |
| 20 mM | 0.1452 mL | 0.7258 mL | 1.4516 mL | 3.6290 mL | |
| 25 mM | 0.1161 mL | 0.5806 mL | 1.1613 mL | 2.9032 mL | |
| 30 mM | 0.0968 mL | 0.4839 mL | 0.9677 mL | 2.4193 mL | |
| 40 mM | 0.0726 mL | 0.3629 mL | 0.7258 mL | 1.8145 mL | |
| 50 mM | 0.0581 mL | 0.2903 mL | 0.5806 mL | 1.4516 mL | |
| 60 mM | 0.0484 mL | 0.2419 mL | 0.4839 mL | 1.2097 mL | |
| 80 mM | 0.0363 mL | 0.1814 mL | 0.3629 mL | 0.9072 mL | |
| 100 mM | 0.0290 mL | 0.1452 mL | 0.2903 mL | 0.7258 mL |
S119-8 Related Classifications
HY-112543 Related Classifications
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