Curculigoside
Based on 9 publication(s) in Google Scholar
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.82%
- No. CAS: 85643-19-2
- Fòrmula: C22H26O11
- Peso molecular:466.44
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Curculigoside
More- Cell Commun Signal. 2024 Oct 11;22(1):488. [Abstract]
- Osteoarthritis Cartilage. 2025 Apr;33(4):412-425. [Abstract]
- Int J Mol Med. 2023 Nov;52(5):107. [Abstract]
- J Ethnopharmacol. 2023 Jan 30:301:115804. [Abstract]
- Life Sci. 2020 Oct 15:259:118356. [Abstract]
- J Orthop Surg Res. 2021 Apr 26;16(1):279. [Abstract]
- Hum Exp Toxicol. Jan-Dec 2022;41:9603271221087146. [Abstract]
- Tissue Cell. 2025 Apr:93:102745. [Abstract]
- Acta Cir Bras. 2025 Aug 18:40:e406825. [Abstract]
Customer Validation & Images
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Histological Imaging/Staining
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ELISA
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WB
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IF
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Flow Cytometry
Actividad biológica
JAK; STAT; NF-κB[1]
Curculigoside (1-64 μg/ml; 72 hours) exerts significant inhibitory effects on MH7A cell viability[1].? Curculigoside (4-16 μg/ml; 24 hours) decreases the protein expression of JAK1, JAK3 and STAT3 compared to the TNF-α group[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MH7A cells
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Concentration:1 μg/ml; 2 μg/ml; 4 μg/ml; 8 μg/ml; 16 μg/ml; 32 μg/ml; 64 μg/ml
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Incubation Time:72 hours
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Result:Had inhibitory effect on MH7A cells.
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Cell Line:MH7A cells
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Concentration:4 μg/ml; 64 μg/ml
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Incubation Time:24 hours
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Result:Downregulated JAK1, JAK3 and STAT3 protein expression.
Chemical Information
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No. CAS 85643-19-2
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Appearance Solid
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Peso molecular 466.44
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Fòrmula C22H26O11
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Color White to off-white
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SMILES
O=C(C(C(OC)=CC=C1)=C1OC)OCC(C=C(O)C=C2)=C2O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (9)
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Journal Impact Factor
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Most Recent
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Cell Commun Signal
Nesfatin-1 enhances vascular smooth muscle calcification through facilitating BMP-2 osteogenic signaling. [Abstract]2024 Oct 11;22(1):488. PMID: 39394127 -
Osteoarthritis Cartilage
Curculigoside upregulates BMAL1 to decrease nucleus pulposus cell apoptosis by inhibiting the JAK/STAT3 pathway. [Abstract]2025 Apr;33(4):412-425. PMID: 39622432 -
Int J Mol Med
Curculigoside mitigates dextran sulfate sodium‑induced colitis by activation of KEAP1‑NRF2 interaction to inhibit oxidative damage and autophagy of intestinal epithelium barrier. [Abstract]2023 Nov;52(5):107. PMID: 37772380
Curculigoside purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Nov;52(5):107. [Abstract]
Colon morphology was analyzed by hematoxylin and eosin staining treated with Curculigoside (CUR) (10, 20 mg/kg, i.g.).
Curculigoside purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Nov;52(5):107. [Abstract]
Serum were determined by ELISA treated with Curculigoside (CUR) (10, 20 mg/kg, i.g.).
Curculigoside purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Nov;52(5):107. [Abstract]
Caco2 cells were treated with Curculigoside (CUR) (10, 20, 30, 40 μM) for 4 h followed by TNF-α (100 ng/ml) for 24 h. The protein levels of ZO-1 and occludin were assessed by western blot.
Curculigoside purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Nov;52(5):107. [Abstract]
Mitochondrial membrane potential was detected using JC‑1 probe treated with Curculigoside (CUR) (20, 40 μM).
Curculigoside purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2023 Nov;52(5):107. [Abstract]
Caco2 cell ROS levels were measured by DCFHDA ROS assay kit treated with Curculigoside (CUR) (20, 40 μM).
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J Ethnopharmacol
Efficacy of curculigoside in protecting against ischemic brain injury through regulation of oxidative stress and NF-κB and PI3K/Akt expression. [Abstract]2023 Jan 30:301:115804. PMID: 36228892 -
Life Sci
2020 Oct 15:259:118356. PMID: 32861798 -
J Orthop Surg Res
Curculigoside promotes osteogenic differentiation of ADSCs to prevent ovariectomized-induced osteoporosis. [Abstract]2021 Apr 26;16(1):279. PMID: 33902663 -
Hum Exp Toxicol
Curculigoside mitigates hepatic ischemia/reperfusion-induced oxidative stress, inflammation, and apoptosis via activation of the Nrf-2/HO-1 pathway. [Abstract]Jan-Dec 2022;41:9603271221087146. PMID: 35331031 -
Tissue Cell
Curculigoside exhibits multiple therapeutic efficacy to induce apoptosis and ferroptosis in osteosarcoma via modulation of ROS and tumor microenvironment. [Abstract]2025 Apr:93:102745. PMID: 39864205 -
Acta Cir Bras
2025 Aug 18:40:e406825. PMID: 40834223
Solvente y solubilidad
DMSO : 100 mg/mL (214.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 2 mg/mL (4.29 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.46 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.46 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.1439 mL | 10.7195 mL | 21.4390 mL | 53.5975 mL |
| DMSO | 5 mM | 0.4288 mL | 2.1439 mL | 4.2878 mL | 10.7195 mL |
| 10 mM | 0.2144 mL | 1.0719 mL | 2.1439 mL | 5.3597 mL | |
| 15 mM | 0.1429 mL | 0.7146 mL | 1.4293 mL | 3.5732 mL | |
| 20 mM | 0.1072 mL | 0.5360 mL | 1.0719 mL | 2.6799 mL | |
| 25 mM | 0.0858 mL | 0.4288 mL | 0.8576 mL | 2.1439 mL | |
| 30 mM | 0.0715 mL | 0.3573 mL | 0.7146 mL | 1.7866 mL | |
| 40 mM | 0.0536 mL | 0.2680 mL | 0.5360 mL | 1.3399 mL | |
| 50 mM | 0.0429 mL | 0.2144 mL | 0.4288 mL | 1.0719 mL | |
| 60 mM | 0.0357 mL | 0.1787 mL | 0.3573 mL | 0.8933 mL | |
| 80 mM | 0.0268 mL | 0.1340 mL | 0.2680 mL | 0.6700 mL | |
| 100 mM | 0.0214 mL | 0.1072 mL | 0.2144 mL | 0.5360 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Curculigoside Related Classifications
HY-N0705 Related Classifications
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