Mmp12 - matrix metallopeptidase 12 Gene

Also Known as Mme

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 117033

About Mmp12

Primary_assembly 8: 4,581,785-4,599,611 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 559 orthologues, 23 paralogues and is associated with 31 phenotypes. Biased expression in Thymus (RPKM 14.7), Spleen (RPKM 5.9) and 5 other tissues.

Summary

Predicted to enable several functions, including core promoter sequence-specific DNA binding activity; metal ion binding activity; and metalloendopeptidase activity. Involved in several processes, including positive regulation of epithelial cell proliferation; regulation of trophoblast cell migration; and response to hypoxia. Predicted to be located in cytoplasm; extracellular space; and nucleus. Used to study crescentic glomerulonephritis. Biomarker of anti-basement membrane glomerulonephritis and crescentic glomerulonephritis. Human ortholog(s) of this gene implicated in Barrett's esophagus; artery disease (multiple); coronary aneurysm; esophagus adenocarcinoma; and multiple sclerosis. Orthologous to human MMP12 (matrix metallopeptidase 12). [provided by Alliance of Genome Resources, Apr 2022]

Mmp12 Products (1)

mRNA Protein Name
NM_053963.2 NP_446415.2 macrophage metalloelastase preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in positive regulation of epithelial cell proliferation IEP
IEP: Inferred from expression pattern
15802269 RGD
involved in regulation of trophoblast cell migration IMP
IMP: Inferred from mutant phenotype
27807143 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
27807143 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15569474 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
12783419 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mmp12 Protein Structure

PG_binding_1

PG_binding_1: pfam01471 (40 - 94)

Peptidase_M10

Peptidase_M10: pfam00413 (115 - 270)

HX

HX: cd00094 (292 - 476)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 477 a.a.
Protein Preferred Names Protein Names

macrophage metalloelastase

  • MMP-12

  • matrix metalloproteinase-12

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-156963 Aderamastat Inhibitor 99.88% Phase 3
HY-171804 Linvemastat Inhibitor 98.30% Phase 2
HY-101276 AZD-1236 Inhibitor 99.62% Phase 2

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120852 JG26 98.14% Unkown
HY-107639 UK-370106 Inhibitor ≥99.0% Unkown
HY-12093 MMP408 Inhibitor 99.04% Unkown
HY-135517 RXP470.1 Inhibitor 99.60% Unkown
HY-114091 PF-00356231 hydrochloride Inhibitor 99.52% Unkown
HY-164826 Acetyl zingerone 99.34% Unkown
HY-P4905 Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 Inhibitor 98.02% Unkown
HY-12093A (R)-MMP408 99.91% Unkown
HY-130391 MMP12-IN-3 Inhibitor ≥99.0% Unkown
HY-113621B Ageladine A dihydrochloride Inhibitor / Unkown
HY-114091A PF-00356231 Inhibitor / Unkown
HY-119185 AZD-6605 / Unkown
HY-120944 BAY-7598 Inhibitor / Unkown
HY-161707 MMP2-IN-4 Inhibitor / Unkown
HY-P6183 LXJ-02 Inducer / Unkown
HY-RS08522 MMP12 Human Pre-designed siRNA Set A / Unkown
HY-RS08523 Mmp12 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08524 Mmp12 Rat Pre-designed siRNA Set A / Unkown
HY-135517A (2R)-RXP470.1 Control 98.70% Unkown
HY-14155 MMP145 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp12 NCBI NCBI:4321