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Kcnq1 - potassium voltage-gated channel, subfamily Q, member 1 Gene

Also Known as Kcna9; KVLQT1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16535

Summary

Enables voltage-gated Potassium Channel activity. Involved in several processes, including animal organ development; inorganic ion homeostasis; and regulation of heart contraction. Acts upstream of or within circulatory system development; negative regulation of gene expression; and regulation of gene expression by genetic imprinting. Located in apical part of cell; neuron projection; and transport vesicle. Part of voltage-gated Potassium Channel complex. Is active in several cellular components, including apical plasma membrane; basolateral part of cell; and ciliary base. Is expressed in several structures, including alimentary system; extraembryonic component; heart; hemolymphoid system gland; and reproductive system. Used to study Jervell-Lange Nielsen syndrome and long QT syndrome 1. Human ortholog(s) of this gene implicated in heart conduction disease (multiple) and long QT syndrome (multiple). Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcnq1 Products (3)

mRNA	Protein	Name
NM_001412611.1	NP_001399540.1	potassium voltage-gated channel subfamily KQT member 1 isoform 2
NM_001412612.1	NP_001399541.1	potassium voltage-gated channel subfamily KQT member 1 isoform 3
NM_008434.3	NP_032460.2	potassium voltage-gated channel subfamily KQT member 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24595108	MGI
enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	8900282	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in adrenergic receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17597584	MGI
involved in auditory receptor cell development	IMP IMP: Inferred from mutant phenotype	26084842	MGI
involved in cardiac conduction	IMP IMP: Inferred from mutant phenotype	23542581	MGI
involved in cardiac muscle contraction	IMP IMP: Inferred from mutant phenotype	17660684	MGI
involved in cellular response to epinephrine stimulus	IMP IMP: Inferred from mutant phenotype	17597584	MGI
involved in chloride ion homeostasis	IMP IMP: Inferred from mutant phenotype	16314573	MGI
involved in cochlea development	IMP IMP: Inferred from mutant phenotype	15891643	MGI
involved in corticosterone secretion	IMP IMP: Inferred from mutant phenotype	17660684	MGI
involved in detection of mechanical stimulus involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	15891643	MGI
acts upstream of or within digestive system process	IMP IMP: Inferred from mutant phenotype	23975432	MGI
involved in erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	16314573	MGI
involved in gastric acid secretion	IMP IMP: Inferred from mutant phenotype	15385447	MGI
involved in gastrin-induced gastric acid secretion	IMP IMP: Inferred from mutant phenotype	17660684	MGI
involved in glucose metabolic process	IMP IMP: Inferred from mutant phenotype	19369585	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	15498462	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	15385447	MGI
involved in inner ear development	IMP IMP: Inferred from mutant phenotype	11120752	MGI
involved in inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	11226272	MGI
involved in intracellular chloride ion homeostasis	IDA IDA: Inferred from direct assay	11527966	MGI
involved in intracellular chloride ion homeostasis	IMP IMP: Inferred from mutant phenotype	11527966	MGI
involved in iodide transport	IMP IMP: Inferred from mutant phenotype	22549510	MGI
involved in membrane repolarization	IMP IMP: Inferred from mutant phenotype	16314573	MGI
involved in membrane repolarization during action potential	IMP IMP: Inferred from mutant phenotype	20368164	MGI
acts upstream of or within membrane repolarization during ventricular cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	12766260	MGI
involved in non-motile cilium assembly	IDA IDA: Inferred from direct assay	26546361	MGI
involved in non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	26546361	MGI
involved in potassium ion homeostasis	IMP IMP: Inferred from mutant phenotype	16314573	MGI
involved in potassium ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	19369585	MGI
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	11527966	MGI
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	11527966	MGI
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	17660684	MGI
involved in regulation of gastric acid secretion	IMP IMP: Inferred from mutant phenotype	16314573	MGI
involved in regulation of heart rate	IMP IMP: Inferred from mutant phenotype	20368164	MGI
involved in regulation of transporter activity	IMP IMP: Inferred from mutant phenotype	24595108	MGI
involved in regulation of ventricular cardiac muscle cell membrane repolarization	IMP IMP: Inferred from mutant phenotype	11226272	MGI
involved in regulation of voltage-gated sodium channel activity	IMP IMP: Inferred from mutant phenotype	23542581	MGI
involved in renal absorption	IMP IMP: Inferred from mutant phenotype	16314573	MGI
involved in renal sodium ion absorption	IMP IMP: Inferred from mutant phenotype	16314573	MGI
involved in response to insulin	IMP IMP: Inferred from mutant phenotype	19369585	MGI
involved in rhythmic behavior	IMP IMP: Inferred from mutant phenotype	15891643	MGI
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	11226272	MGI
involved in social behavior	IMP IMP: Inferred from mutant phenotype	15498462	MGI
involved in sodium ion transport	IDA IDA: Inferred from direct assay	11527966	MGI
involved in sodium ion transport	IMP IMP: Inferred from mutant phenotype	11527966	MGI
involved in stomach development	IMP IMP: Inferred from mutant phenotype	15385447	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in apical part of cell	IDA IDA: Inferred from direct assay	16896189	MGI
is active in apical plasma membrane	IDA IDA: Inferred from direct assay	11223304	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16901941	MGI
is active in basolateral part of cell	IDA IDA: Inferred from direct assay	11527966	MGI
is active in ciliary base	IDA IDA: Inferred from direct assay	26546361	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	16896189	MGI
located in lumenal side of membrane	IDA IDA: Inferred from direct assay	16901941	MGI
is active in neuron projection	IMP IMP: Inferred from mutant phenotype	20368164	MGI
is active in neuronal cell body	IMP IMP: Inferred from mutant phenotype	20368164	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	16901941	MGI
part of potassium channel complex	IDA IDA: Inferred from direct assay	19218243	MGI
is active in transport vesicle	IDA IDA: Inferred from direct assay	23154976	MGI
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	24595108	MGI
part of voltage-gated potassium channel complex	IPI IPI: Inferred from physical interaction	8900282	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
potassium voltage-gated channel subfamily KQT member 1	IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 KQT-like 1 voltage-gated potassium channel subunit Kv7.1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108577	XE991 dihydrochloride	Inhibitor	/	Unkown
HY-12343	ML277	Activator	98.46%	Unkown
HY-108577A	XE991	Inhibitor	99.69%	Unkown
HY-108591	L-364,373	Activator	99.65%	Unkown
HY-18063	ML252	Inhibitor	99.9%	Unkown
HY-108587	ICA 110381	Modulator	99.80%	Unkown
HY-108592	UCL 2077	Inhibitor	98.91%	Unkown
HY-145992	KCNQ1 activator-1	Activator	99.03%	Unkown
HY-18063A	ML252 hydrochloride	Inhibitor	98.5%	Unkown
HY-117174	L-735821	Inhibitor	/	Unkown
HY-121520	Docosahexaenoyl glycine	Activator	/	Unkown
HY-122504	Linoleoyl glycine	Inhibitor	/	Unkown
HY-179065	VU0494372	Activator	/	Unkown
HY-183323	MmpL3-IN-6		/	Unkown
HY-184207	Zinc13732787	Inhibitor	/	Unkown
HY-RS07173	KCNQ1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-121977	IKs124	Inhibitor	/	Unkown
HY-RS18286	Kcnq1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24764	Kcnq1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnq1	NCBI	NCBI:3784