Srd5a1 - steroid 5 alpha-reductase 1 Gene

Also Known as S5AR 1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24950

Summary

Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity; NADPH binding activity; and amide binding activity. Involved in several processes, including animal organ development; cellular hormone metabolic process; and cellular response to organic cyclic compound. Located in several cellular components, including cell body fiber; neuronal cell body; and perinuclear region of cytoplasm. Used to study prostate Cancer. Biomarker of hyperprolactinemia; hypothyroidism; obesity; prostate cancer; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in prostate Cancer and prostatic hypertrophy. Orthologous to human SRD5A1 (steroid 5 alpha-reductase 1). [provided by Alliance of Genome Resources, Apr 2022]

Srd5a1 Products (1)

mRNA Protein Name
NM_017070.3 NP_058766.2 3-oxo-5-alpha-steroid 4-dehydrogenase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity IDA
IDA: Inferred from direct assay
7482629 RGD
enables NADPH binding IDA
IDA: Inferred from direct assay
11377984 RGD
enables amide binding IDA
IDA: Inferred from direct assay
9090798 RGD
Biological Process GO Annotation Evidence References Source
involved in androgen biosynthetic process IDA
IDA: Inferred from direct assay
12606426 RGD
involved in androgen catabolic process IDA
IDA: Inferred from direct assay
2339109 RGD
involved in androgen metabolic process IDA
IDA: Inferred from direct assay
20954080 RGD
involved in bone development IEP
IEP: Inferred from expression pattern
15012600 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
14997014 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
15004407 RGD
involved in cellular response to epinephrine stimulus IEP
IEP: Inferred from expression pattern
14997014 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
15312799 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
15249139 RGD
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
20810561 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15936112 RGD
involved in cellular response to starvation IEP
IEP: Inferred from expression pattern
9729333 RGD
involved in cellular response to testosterone stimulus IEP
IEP: Inferred from expression pattern
15004407 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
8770891 RGD
involved in diterpenoid metabolic process IEP
IEP: Inferred from expression pattern
14997014 RGD
involved in female genitalia development IEP
IEP: Inferred from expression pattern
9142501 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
8770891 RGD
involved in hypothalamus development IEP
IEP: Inferred from expression pattern
8770891 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
8770891 RGD
involved in male genitalia development IEP
IEP: Inferred from expression pattern
9142501 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
12606426 RGD
involved in pituitary gland development IEP
IEP: Inferred from expression pattern
8770891 RGD
involved in progesterone metabolic process IDA
IDA: Inferred from direct assay
9202401 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
9504773 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
19793540 RGD
involved in response to follicle-stimulating hormone IEP
IEP: Inferred from expression pattern
12630924 RGD
involved in response to fungicide IEP
IEP: Inferred from expression pattern
19728174 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
10067850 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
20045012 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17940878 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
16595696 RGD
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
1314830 RGD
involved in serotonin metabolic process IEP
IEP: Inferred from expression pattern
15936112 RGD
involved in spinal cord development IEP
IEP: Inferred from expression pattern
8770891 RGD
involved in steroid biosynthetic process IDA
IDA: Inferred from direct assay
7482629 RGD
involved in thalamus development IEP
IEP: Inferred from expression pattern
8770891 RGD
involved in urogenital system development IEP
IEP: Inferred from expression pattern
8584033 RGD
Cellular Component GO Annotation Evidence References Source
located in cell body fiber IDA
IDA: Inferred from direct assay
15305365 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15305365 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
7553073 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

3-oxo-5-alpha-steroid 4-dehydrogenase 1

  • SR type 1

  • steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-152094 SRD5A1-IN-1 Inhibitor 99.82% Unkown
HY-RS13754 SRD5A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175719 SRD5A1-IN-2 Inhibitor / Unkown
HY-RS19076 Srd5a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25567 Srd5a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Srd5a1 NCBI NCBI:6715