Acvrl1 - activin A receptor like type 1 Gene

Also Known as R3; R-3; Alk1; SETHKIR

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25237

About Acvrl1

Primary_assembly 7: 132,239,729-132,256,591 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 358 orthologues, 11 paralogues and is associated with 14 phenotypes. Biased expression in Lung (RPKM 529.2), Heart (RPKM 83.6) and 6 other tissues.

Summary

Predicted to enable several functions, including ATP binding activity; activin binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in response to hypoxia. Located in cell surface; dendrite; and neuronal cell body. Biomarker of pulmonary hypertension and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary hemorrhagic telangiectasia and pulmonary hypertension. Orthologous to human ACVRL1 (Activin A receptor like type 1). [provided by Alliance of Genome Resources, Apr 2022]

Acvrl1 Products (1)

mRNA Protein Name
NM_022441.2 NP_071886.1 serine/threonine-protein kinase receptor R3 precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
17515860 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15781474 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15781474 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15781474 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Acvrl1 Protein Structure

TGF_beta_GS

TGF_beta_GS: pfam08515 (174 - 200)

STKc_ACVR1_ALK1

STKc_ACVR1_ALK1: cd14142 (196 - 493)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase receptor R3

  • Activin receptor like kinase 1

  • SKR3

  • TGF-B superfamily receptor type I

  • TSR-I

  • activin A receptor type II-like 1

  • activin A receptor type IL

Recombinant Acvrl1 Proteins

Cat. No. Product Name Accession Purity
HY-P72820 ALK-1 Protein, Rat (HEK293, His-Fc) P80203 (D23-A118) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99353 Ascrinvacumab Inhibitor 97.45% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00251 ACVRL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00252 Acvrl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00253 Acvrl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174781 Human ACVRL1 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Acvrl1 NCBI NCBI:94